Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079605101> ?p ?o ?g. }
- W2079605101 endingPage "116" @default.
- W2079605101 startingPage "91" @default.
- W2079605101 abstract "Detailed pathophysiological findings of secondary damage phenomena after spinal cord injury (SCI) as well as the identification of inhibitory and neurotrophic proteins have yielded a plethora of experimental therapeutic approaches. Main targets are (i) to minimize secondary damage progression (neuroprotection), (ii) to foster axon conduction (neurorestoration) and (iii) to supply a permissive environment to promote axonal sprouting (neuroregenerative therapies). Pre-clinical studies have raised hope in functional recovery through the antagonism of growth inhibitors, application of growth factors, cell transplantation, and vaccination strategies. To date, even though based on successful pre-clinical animal studies, results of clinical trials are characterized by dampened effects attributable to difficulties in the study design (patient heterogeneity) and species differences. A combination of complementary therapeutic strategies might be considered pre-requisite for future synergistic approaches. Here, we line out pre-clinical interventions resulting in improved functional neurological outcome after spinal cord injury and track them on their intended way to bedside." @default.
- W2079605101 created "2016-06-24" @default.
- W2079605101 creator A5009361981 @default.
- W2079605101 creator A5013535977 @default.
- W2079605101 creator A5043246811 @default.
- W2079605101 creator A5051780753 @default.
- W2079605101 creator A5063660131 @default.
- W2079605101 creator A5084643347 @default.
- W2079605101 creator A5086342977 @default.
- W2079605101 date "2006-02-01" @default.
- W2079605101 modified "2023-10-12" @default.
- W2079605101 title "Experimental strategies to promote spinal cord regeneration—an integrative perspective" @default.
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