Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079612977> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2079612977 endingPage "421" @default.
- W2079612977 startingPage "416" @default.
- W2079612977 abstract "The antiviral activity of five structurally related pyrimidine nucleosides, E-5-propenyl-2'-deoxyuridine, 5-allyl-2'-deoxyuridine, E-5-(1-butenyl)-2'-deoxyuridine, 5-(2-butenyl)-2'-deoxyuridine, and 5-butyl-2'-deoxyuridine, in cell culture against herpes simplex virus type 1 was examined. Analogs in which the C-C double bond of the 5-substituent was in conjugation with the pyrimidine ring were more potent antiviral drugs than were the corresponding nonconjugated and alkyl-substituted analogs. Differences in antiviral activity similar to those observed in cell culture occurred in virus-infected mice. The molecular basis for the greater antiviral activity of the conjugated isomers was investigated. It was observed that the conjugated isomer E-5-propenyl-2'-deoxyuridine had a greater affinity for virus thymidine kinase and, as the 5'-triphosphate, for virus DNA polymerase than did the nonconjugated isomer 5-allyl-2'-deoxyuridine. The results are discussed in relation to other data in the literature." @default.
- W2079612977 created "2016-06-24" @default.
- W2079612977 creator A5022208988 @default.
- W2079612977 creator A5034807817 @default.
- W2079612977 creator A5039924463 @default.
- W2079612977 creator A5047837571 @default.
- W2079612977 creator A5050352096 @default.
- W2079612977 creator A5064187939 @default.
- W2079612977 creator A5072422110 @default.
- W2079612977 date "1983-03-01" @default.
- W2079612977 modified "2023-09-26" @default.
- W2079612977 title "Possible molecular basis for antiviral activity of certain 5-substituted deoxyuridines" @default.
- W2079612977 cites W11243260 @default.
- W2079612977 cites W1546233377 @default.
- W2079612977 cites W1563895541 @default.
- W2079612977 cites W161096252 @default.
- W2079612977 cites W1621272010 @default.
- W2079612977 cites W1963485266 @default.
- W2079612977 cites W1974429192 @default.
- W2079612977 cites W1984444755 @default.
- W2079612977 cites W2025508718 @default.
- W2079612977 cites W2029030763 @default.
- W2079612977 cites W2029671220 @default.
- W2079612977 cites W2036259401 @default.
- W2079612977 cites W2039533427 @default.
- W2079612977 cites W2041348353 @default.
- W2079612977 cites W2044980847 @default.
- W2079612977 cites W2077845104 @default.
- W2079612977 cites W2091439387 @default.
- W2079612977 cites W2095333277 @default.
- W2079612977 cites W2142992472 @default.
- W2079612977 cites W2159818060 @default.
- W2079612977 cites W2163480052 @default.
- W2079612977 cites W2318288796 @default.
- W2079612977 cites W2321344708 @default.
- W2079612977 cites W4298434897 @default.
- W2079612977 cites W877923976 @default.
- W2079612977 doi "https://doi.org/10.1128/aac.23.3.416" @default.
- W2079612977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/184663" @default.
- W2079612977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6303212" @default.
- W2079612977 hasPublicationYear "1983" @default.
- W2079612977 type Work @default.
- W2079612977 sameAs 2079612977 @default.
- W2079612977 citedByCount "14" @default.
- W2079612977 crossrefType "journal-article" @default.
- W2079612977 hasAuthorship W2079612977A5022208988 @default.
- W2079612977 hasAuthorship W2079612977A5034807817 @default.
- W2079612977 hasAuthorship W2079612977A5039924463 @default.
- W2079612977 hasAuthorship W2079612977A5047837571 @default.
- W2079612977 hasAuthorship W2079612977A5050352096 @default.
- W2079612977 hasAuthorship W2079612977A5064187939 @default.
- W2079612977 hasAuthorship W2079612977A5072422110 @default.
- W2079612977 hasBestOaLocation W20796129772 @default.
- W2079612977 hasConcept C159047783 @default.
- W2079612977 hasConcept C185592680 @default.
- W2079612977 hasConcept C2522874641 @default.
- W2079612977 hasConcept C2776147627 @default.
- W2079612977 hasConcept C2777108182 @default.
- W2079612977 hasConcept C2777111502 @default.
- W2079612977 hasConcept C2779321679 @default.
- W2079612977 hasConcept C2781196997 @default.
- W2079612977 hasConcept C552990157 @default.
- W2079612977 hasConcept C55493867 @default.
- W2079612977 hasConcept C71240020 @default.
- W2079612977 hasConcept C86803240 @default.
- W2079612977 hasConceptScore W2079612977C159047783 @default.
- W2079612977 hasConceptScore W2079612977C185592680 @default.
- W2079612977 hasConceptScore W2079612977C2522874641 @default.
- W2079612977 hasConceptScore W2079612977C2776147627 @default.
- W2079612977 hasConceptScore W2079612977C2777108182 @default.
- W2079612977 hasConceptScore W2079612977C2777111502 @default.
- W2079612977 hasConceptScore W2079612977C2779321679 @default.
- W2079612977 hasConceptScore W2079612977C2781196997 @default.
- W2079612977 hasConceptScore W2079612977C552990157 @default.
- W2079612977 hasConceptScore W2079612977C55493867 @default.
- W2079612977 hasConceptScore W2079612977C71240020 @default.
- W2079612977 hasConceptScore W2079612977C86803240 @default.
- W2079612977 hasIssue "3" @default.
- W2079612977 hasLocation W20796129771 @default.
- W2079612977 hasLocation W20796129772 @default.
- W2079612977 hasOpenAccess W2079612977 @default.
- W2079612977 hasPrimaryLocation W20796129771 @default.
- W2079612977 hasRelatedWork W1969833256 @default.
- W2079612977 hasRelatedWork W2000255487 @default.
- W2079612977 hasRelatedWork W2026282868 @default.
- W2079612977 hasRelatedWork W2027741865 @default.
- W2079612977 hasRelatedWork W2040001042 @default.
- W2079612977 hasRelatedWork W2063753635 @default.
- W2079612977 hasRelatedWork W2073270396 @default.
- W2079612977 hasRelatedWork W2082608583 @default.
- W2079612977 hasRelatedWork W2145335159 @default.
- W2079612977 hasRelatedWork W2422388878 @default.
- W2079612977 hasVolume "23" @default.
- W2079612977 isParatext "false" @default.
- W2079612977 isRetracted "false" @default.
- W2079612977 magId "2079612977" @default.
- W2079612977 workType "article" @default.