Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079613593> ?p ?o ?g. }
- W2079613593 endingPage "966" @default.
- W2079613593 startingPage "951" @default.
- W2079613593 abstract "Peroxynitrite (PN; ONOO⁻) and its reactive oxygen precursor superoxide (SO; O₂•⁻) are critically important in the development of pain of several etiologies including pain associated with chronic use of opiates such as morphine (also known as opiate-induced hyperalgesia and antinociceptive tolerance). This is now an emerging field in which considerable progress has been made in terms of understanding the relative contributions of SO, PN, and nitroxidative stress in pain signaling at the molecular and biochemical levels. Aggressive research in this area is poised to provide the pharmacological basis for development of novel nonnarcotic analgesics that are based upon the unique ability to selectively eliminate SO and/or PN. As we have a better understanding of the roles of SO and PN in pathophysiological settings, targeting PN may be a better therapeutic strategy than targeting SO. This is because, unlike PN, which has no currently known beneficial role, SO may play a significant role in learning and memory. Thus, the best approach may be to spare SO while directly targeting its downstream product, PN. Over the past 15 years, our team has spearheaded research concerning the roles of SO and PN in pain and these results are currently leading to the development of solid therapeutic strategies in this important area." @default.
- W2079613593 created "2016-06-24" @default.
- W2079613593 creator A5009768215 @default.
- W2079613593 creator A5039485406 @default.
- W2079613593 creator A5047649675 @default.
- W2079613593 creator A5052226319 @default.
- W2079613593 date "2011-09-01" @default.
- W2079613593 modified "2023-10-14" @default.
- W2079613593 title "Roles of reactive oxygen and nitrogen species in pain" @default.
- W2079613593 cites W134461097 @default.
- W2079613593 cites W1486972213 @default.
- W2079613593 cites W1497341558 @default.
- W2079613593 cites W1500202490 @default.
- W2079613593 cites W1511198581 @default.
- W2079613593 cites W1512720139 @default.
- W2079613593 cites W1531160152 @default.
- W2079613593 cites W1536272467 @default.
- W2079613593 cites W1540277158 @default.
- W2079613593 cites W1580245730 @default.
- W2079613593 cites W1582753616 @default.
- W2079613593 cites W1585708861 @default.
- W2079613593 cites W1600193814 @default.
- W2079613593 cites W1604766895 @default.
- W2079613593 cites W1607257685 @default.
- W2079613593 cites W161395021 @default.
- W2079613593 cites W1851475993 @default.
- W2079613593 cites W1883732752 @default.
- W2079613593 cites W1884333838 @default.
- W2079613593 cites W1895906477 @default.
- W2079613593 cites W1896952141 @default.
- W2079613593 cites W1923918181 @default.
- W2079613593 cites W1927752519 @default.
- W2079613593 cites W1936866440 @default.
- W2079613593 cites W1939319907 @default.
- W2079613593 cites W1940436875 @default.
- W2079613593 cites W1942930266 @default.
- W2079613593 cites W1961139916 @default.
- W2079613593 cites W1964137248 @default.
- W2079613593 cites W1964945987 @default.
- W2079613593 cites W1965066118 @default.
- W2079613593 cites W1965675103 @default.
- W2079613593 cites W1965948569 @default.
- W2079613593 cites W1966456328 @default.
- W2079613593 cites W1967372817 @default.
- W2079613593 cites W1968130780 @default.
- W2079613593 cites W1968145097 @default.
- W2079613593 cites W1969400861 @default.
- W2079613593 cites W1969854703 @default.
- W2079613593 cites W1969901996 @default.
- W2079613593 cites W1970008312 @default.
- W2079613593 cites W1970911936 @default.
- W2079613593 cites W1971256693 @default.
- W2079613593 cites W1971320695 @default.
- W2079613593 cites W1971335269 @default.
- W2079613593 cites W1971754431 @default.
- W2079613593 cites W1972837921 @default.
- W2079613593 cites W1974191568 @default.
- W2079613593 cites W1975519000 @default.
- W2079613593 cites W1975693853 @default.
- W2079613593 cites W1977811447 @default.
- W2079613593 cites W1977984211 @default.
- W2079613593 cites W1978897740 @default.
- W2079613593 cites W1979415715 @default.
- W2079613593 cites W1980356075 @default.
- W2079613593 cites W1981289966 @default.
- W2079613593 cites W1981314372 @default.
- W2079613593 cites W1981803317 @default.
- W2079613593 cites W1981837661 @default.
- W2079613593 cites W1982249239 @default.
- W2079613593 cites W1982629087 @default.
- W2079613593 cites W1983013119 @default.
- W2079613593 cites W1983043018 @default.
- W2079613593 cites W1983197885 @default.
- W2079613593 cites W1983348654 @default.
- W2079613593 cites W1984203003 @default.
- W2079613593 cites W1984526977 @default.
- W2079613593 cites W1984833931 @default.
- W2079613593 cites W1984854027 @default.
- W2079613593 cites W1984890353 @default.
- W2079613593 cites W1984929776 @default.
- W2079613593 cites W1985148106 @default.
- W2079613593 cites W1985413716 @default.
- W2079613593 cites W1985621680 @default.
- W2079613593 cites W1986219537 @default.
- W2079613593 cites W1986235007 @default.
- W2079613593 cites W1987096917 @default.
- W2079613593 cites W1987783006 @default.
- W2079613593 cites W1987970258 @default.
- W2079613593 cites W1988308748 @default.
- W2079613593 cites W1989804049 @default.
- W2079613593 cites W1990477050 @default.
- W2079613593 cites W1991326865 @default.
- W2079613593 cites W1991477055 @default.
- W2079613593 cites W1991537801 @default.
- W2079613593 cites W1991701465 @default.
- W2079613593 cites W1992245975 @default.
- W2079613593 cites W1992259067 @default.
- W2079613593 cites W1993536876 @default.