Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079628098> ?p ?o ?g. }
- W2079628098 endingPage "595" @default.
- W2079628098 startingPage "586" @default.
- W2079628098 abstract "Abstract Objective Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease. Methods Fifty‐two subjects were randomized to unilateral STN or GPi DBS. The co‐primary outcome measures were the Visual Analog Mood Scale, and verbal fluency (semantic and letter) at 7 months post‐DBS in the optimal setting compared to pre‐DBS. At 7 months post‐DBS, subjects were tested in four randomized/counterbalanced conditions ( optimal, ventral, dorsal, and off DBS). Results Forty‐five subjects (23 GPi, 22 STN) completed the protocol. The study revealed no difference between STN and GPi DBS in the change of co‐primary mood and cognitive outcomes pre‐ to post‐DBS in the optimal setting (Hotelling's T 2 test: p = 0.16 and 0.08 respectively). Subjects in both targets were less “happy”, less “energetic” and more “confused” when stimulated ventrally. Comparison of the other 3 DBS conditions to pre‐DBS showed a larger deterioration of letter verbal fluency in STN, especially when off DBS. There was no difference in UPDRS motor improvement between targets. Interpretation There were no significant differences in the co‐primary outcome measures (mood and cognition) between STN and GPi in the optimal DBS state. Adverse mood effects occurred ventrally in both targets. A worsening of letter verbal fluency was seen in STN. The persistence of deterioration in verbal fluency in the off STN DBS state was suggestive of a surgical rather than a stimulation‐induced effect. Similar motor improvement were observed with both STN and GPi DBS. Ann Neurol 2009" @default.
- W2079628098 created "2016-06-24" @default.
- W2079628098 creator A5004888152 @default.
- W2079628098 creator A5014713285 @default.
- W2079628098 creator A5019572514 @default.
- W2079628098 creator A5033292275 @default.
- W2079628098 creator A5034268893 @default.
- W2079628098 creator A5039903147 @default.
- W2079628098 creator A5045780022 @default.
- W2079628098 creator A5052932917 @default.
- W2079628098 creator A5053337479 @default.
- W2079628098 creator A5054711513 @default.
- W2079628098 creator A5055950112 @default.
- W2079628098 creator A5056545815 @default.
- W2079628098 creator A5056665061 @default.
- W2079628098 creator A5082659140 @default.
- W2079628098 creator A5088360078 @default.
- W2079628098 creator A5089767875 @default.
- W2079628098 date "2009-03-13" @default.
- W2079628098 modified "2023-10-18" @default.
- W2079628098 title "Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: The COMPARE Trial" @default.
- W2079628098 cites W1965366154 @default.
- W2079628098 cites W1966653878 @default.
- W2079628098 cites W1977314903 @default.
- W2079628098 cites W1983297775 @default.
- W2079628098 cites W1983965289 @default.
- W2079628098 cites W1987221939 @default.
- W2079628098 cites W1995161963 @default.
- W2079628098 cites W2003581012 @default.
- W2079628098 cites W2008464919 @default.
- W2079628098 cites W2008560062 @default.
- W2079628098 cites W2012038219 @default.
- W2079628098 cites W2018091645 @default.
- W2079628098 cites W2038095860 @default.
- W2079628098 cites W2038805077 @default.
- W2079628098 cites W2049483623 @default.
- W2079628098 cites W2056145524 @default.
- W2079628098 cites W2057935527 @default.
- W2079628098 cites W2060400480 @default.
- W2079628098 cites W2063179842 @default.
- W2079628098 cites W2079603215 @default.
- W2079628098 cites W2081661802 @default.
- W2079628098 cites W2089036931 @default.
- W2079628098 cites W2102491127 @default.
- W2079628098 cites W2108157570 @default.
- W2079628098 cites W2119329187 @default.
- W2079628098 cites W2123661522 @default.
- W2079628098 cites W2123984617 @default.
- W2079628098 cites W2124227727 @default.
- W2079628098 cites W2148310701 @default.
- W2079628098 cites W2150499782 @default.
- W2079628098 cites W2150607280 @default.
- W2079628098 cites W2151320291 @default.
- W2079628098 cites W2156749100 @default.
- W2079628098 cites W2156969587 @default.
- W2079628098 cites W2169247253 @default.
- W2079628098 cites W2338643926 @default.
- W2079628098 cites W2412955003 @default.
- W2079628098 cites W24345798 @default.
- W2079628098 cites W3025643029 @default.
- W2079628098 doi "https://doi.org/10.1002/ana.21596" @default.
- W2079628098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2692580" @default.
- W2079628098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19288469" @default.
- W2079628098 hasPublicationYear "2009" @default.
- W2079628098 type Work @default.
- W2079628098 sameAs 2079628098 @default.
- W2079628098 citedByCount "439" @default.
- W2079628098 countsByYear W20796280982012 @default.
- W2079628098 countsByYear W20796280982013 @default.
- W2079628098 countsByYear W20796280982014 @default.
- W2079628098 countsByYear W20796280982015 @default.
- W2079628098 countsByYear W20796280982016 @default.
- W2079628098 countsByYear W20796280982017 @default.
- W2079628098 countsByYear W20796280982018 @default.
- W2079628098 countsByYear W20796280982019 @default.
- W2079628098 countsByYear W20796280982020 @default.
- W2079628098 countsByYear W20796280982021 @default.
- W2079628098 countsByYear W20796280982022 @default.
- W2079628098 countsByYear W20796280982023 @default.
- W2079628098 crossrefType "journal-article" @default.
- W2079628098 hasAuthorship W2079628098A5004888152 @default.
- W2079628098 hasAuthorship W2079628098A5014713285 @default.
- W2079628098 hasAuthorship W2079628098A5019572514 @default.
- W2079628098 hasAuthorship W2079628098A5033292275 @default.
- W2079628098 hasAuthorship W2079628098A5034268893 @default.
- W2079628098 hasAuthorship W2079628098A5039903147 @default.
- W2079628098 hasAuthorship W2079628098A5045780022 @default.
- W2079628098 hasAuthorship W2079628098A5052932917 @default.
- W2079628098 hasAuthorship W2079628098A5053337479 @default.
- W2079628098 hasAuthorship W2079628098A5054711513 @default.
- W2079628098 hasAuthorship W2079628098A5055950112 @default.
- W2079628098 hasAuthorship W2079628098A5056545815 @default.
- W2079628098 hasAuthorship W2079628098A5056665061 @default.
- W2079628098 hasAuthorship W2079628098A5082659140 @default.
- W2079628098 hasAuthorship W2079628098A5088360078 @default.
- W2079628098 hasAuthorship W2079628098A5089767875 @default.
- W2079628098 hasBestOaLocation W20796280982 @default.
- W2079628098 hasConcept C118552586 @default.