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- W2079631970 abstract "Pig liver cell nuclei were purified by use of Triton X-100 and centrifugation in 2.4M sucrose. The purified nuclei were virtually free of whole cells, erythrocytes and cytoplasmic organelles as shown by microscopic examination and the low activity of cytoplasmic marker enzymes when compared to the whole homogenate and the unpurified nuclear preparation. When l,2-3H-testosterone was incubated with the purified pig liver nuclei and the metabolites separated by thin layer and paper chromatography Δ4-androstenedione was the major metabolite formed in the presence of NADP+ or NAD+. The androstenedione was identified by reverse isotope dilution. The optimal pH for the nuclear 17β-hydroxysteroid dehydrogenase enzyme activity was 8.2 with NADP+ and 8.0 with NAD+. This is in contrast with the microsomal enzyme, which showed an optimal pH of 9.0 with NADP+ and 9.5 with NAD+. It is concluded that a 17β- hydroxysteroid dehydrogenase which acts on the testosterone is present in pig liver cell nuclei. Of the total homo..." @default.
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- W2079631970 date "1971-07-01" @default.
- W2079631970 modified "2023-09-26" @default.
- W2079631970 title "Conversion of Testosterone to Androstenedione by the Nuclear Fraction of Pig Liver1" @default.
- W2079631970 doi "https://doi.org/10.1210/endo-89-1-135" @default.
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