FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079634519> ?p ?o ?g. }

• W2079634519 endingPage "178" @default.
• W2079634519 startingPage "167" @default.
• W2079634519 abstract "During development norepinephrine plays a role in determining the morphologic organization of the CNS and the density and future responsiveness of adrenergic receptors. α-2 Adrenergic receptors, one of three adrenergic receptor types, regulate important adult CNS functions and may have a distinct role during development. We examined α-2 receptor distribution and density in the rat brain at postnatal days 1, 5, 10, 15, 21, 28 and in adults using the antagonist [3H]RX821002 for autoradiography. Binding kinetics and pharmacology for α-2 adrenergic receptors were the same in adults and neonates. There was an overall increase in α-2 receptor levels during postnatal development with great variability in pattern and timing of receptor density changes among brain regions. Three major patterns were apparent. First, in many regions receptor density increased during postnatal development, generally reaching adult levels around postnatal day 15. Within this group there was variability in timing between regions and there were several regions with receptor densities higher than adult levels during the postnatal period. Second, there were regions with very high levels of receptors at birth and little or no change in density during the postnatal period. Third, some regions demonstrated decreasing or transient expression of α-2 adrenergic receptors in the course of postnatal development, including white matter regions, cerebellum and many brainstem nuclei, suggesting specific roles for α-2 receptors during development. This study investigates the development of α-2 adrenergic receptors in the rat CNS. It demonstrates there is region-specific regulation of α-2 receptor development and identifies brain regions where these receptors may play a specific and critical role in the regulation normal development." @default.
• W2079634519 created "2016-06-24" @default.
• W2079634519 creator A5006951599 @default.
• W2079634519 creator A5025691651 @default.
• W2079634519 creator A5039698831 @default.
• W2079634519 creator A5046677897 @default.
• W2079634519 creator A5069843653 @default.
• W2079634519 creator A5073526947 @default.
• W2079634519 creator A5076665385 @default.
• W2079634519 date "2004-01-01" @default.
• W2079634519 modified "2023-10-15" @default.
• W2079634519 title "Alpha-2 adrenergic receptor development in rat CNS: an autoradiographic study" @default.
• W2079634519 cites W1528722660 @default.
• W2079634519 cites W1963690154 @default.
• W2079634519 cites W1967921156 @default.
• W2079634519 cites W1970986902 @default.
• W2079634519 cites W1975809163 @default.
• W2079634519 cites W1988933620 @default.
• W2079634519 cites W1992135583 @default.
• W2079634519 cites W1996340413 @default.
• W2079634519 cites W2015676539 @default.
• W2079634519 cites W2023358654 @default.
• W2079634519 cites W2026591116 @default.
• W2079634519 cites W2026793290 @default.
• W2079634519 cites W2032996897 @default.
• W2079634519 cites W2034609256 @default.
• W2079634519 cites W2041676666 @default.
• W2079634519 cites W2042348492 @default.
• W2079634519 cites W2043457433 @default.
• W2079634519 cites W2045087265 @default.
• W2079634519 cites W2049730317 @default.
• W2079634519 cites W2053740633 @default.
• W2079634519 cites W2060722431 @default.
• W2079634519 cites W2064863480 @default.
• W2079634519 cites W2076790326 @default.
• W2079634519 cites W2077916586 @default.
• W2079634519 cites W2080609613 @default.
• W2079634519 cites W2083875392 @default.
• W2079634519 cites W2089108617 @default.
• W2079634519 cites W2090938047 @default.
• W2079634519 cites W2092052553 @default.
• W2079634519 cites W2147608198 @default.
• W2079634519 cites W2154841062 @default.
• W2079634519 cites W2187733668 @default.
• W2079634519 cites W2241781610 @default.
• W2079634519 cites W4249990067 @default.
• W2079634519 doi "https://doi.org/10.1016/j.neuroscience.2003.09.004" @default.
• W2079634519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14667451" @default.
• W2079634519 hasPublicationYear "2004" @default.
• W2079634519 type Work @default.
• W2079634519 sameAs 2079634519 @default.
• W2079634519 citedByCount "98" @default.
• W2079634519 countsByYear W20796345192012 @default.
• W2079634519 countsByYear W20796345192013 @default.
• W2079634519 countsByYear W20796345192014 @default.
• W2079634519 countsByYear W20796345192015 @default.
• W2079634519 countsByYear W20796345192016 @default.
• W2079634519 countsByYear W20796345192017 @default.
• W2079634519 countsByYear W20796345192018 @default.
• W2079634519 countsByYear W20796345192019 @default.
• W2079634519 countsByYear W20796345192020 @default.
• W2079634519 countsByYear W20796345192021 @default.
• W2079634519 countsByYear W20796345192022 @default.
• W2079634519 countsByYear W20796345192023 @default.
• W2079634519 crossrefType "journal-article" @default.
• W2079634519 hasAuthorship W2079634519A5006951599 @default.
• W2079634519 hasAuthorship W2079634519A5025691651 @default.
• W2079634519 hasAuthorship W2079634519A5039698831 @default.
• W2079634519 hasAuthorship W2079634519A5046677897 @default.
• W2079634519 hasAuthorship W2079634519A5069843653 @default.
• W2079634519 hasAuthorship W2079634519A5073526947 @default.
• W2079634519 hasAuthorship W2079634519A5076665385 @default.
• W2079634519 hasConcept C121332964 @default.
• W2079634519 hasConcept C126322002 @default.
• W2079634519 hasConcept C134018914 @default.
• W2079634519 hasConcept C169760540 @default.
• W2079634519 hasConcept C170493617 @default.
• W2079634519 hasConcept C172773627 @default.
• W2079634519 hasConcept C24890656 @default.
• W2079634519 hasConcept C26702167 @default.
• W2079634519 hasConcept C2778938600 @default.
• W2079634519 hasConcept C2781291010 @default.
• W2079634519 hasConcept C40465926 @default.
• W2079634519 hasConcept C529278444 @default.
• W2079634519 hasConcept C71924100 @default.
• W2079634519 hasConcept C86803240 @default.
• W2079634519 hasConceptScore W2079634519C121332964 @default.
• W2079634519 hasConceptScore W2079634519C126322002 @default.
• W2079634519 hasConceptScore W2079634519C134018914 @default.
• W2079634519 hasConceptScore W2079634519C169760540 @default.
• W2079634519 hasConceptScore W2079634519C170493617 @default.
• W2079634519 hasConceptScore W2079634519C172773627 @default.
• W2079634519 hasConceptScore W2079634519C24890656 @default.
• W2079634519 hasConceptScore W2079634519C26702167 @default.
• W2079634519 hasConceptScore W2079634519C2778938600 @default.
• W2079634519 hasConceptScore W2079634519C2781291010 @default.
• W2079634519 hasConceptScore W2079634519C40465926 @default.
• W2079634519 hasConceptScore W2079634519C529278444 @default.

• next