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• W2079646310 startingPage "259" @default.
• W2079646310 abstract "We developed a novel motoneuron model to examine the role of voltage-independent, Ca2+-activated potassium conductance (AHP conductance, or gAHP) in regulating repetitive firing. In addition to gAHP, the model also includes five voltage-gated conductances and a system that can reproduce Ca2+ dynamics in the cytoplasm. Conductance kinetics were based on empirical data, and the model reproduced the piecewise linear, steady-state frequency–current relationship (f–I curve). The model revealed that gAHP has a “braking effect” that suppresses spike generation and thereby reduces firing frequency; the magnitude of the reduction in firing frequency is proportional to the temporal average of gAHP activation; and the level of activation depends on the magnitude of the injected current. Moreover, plotting the activation level as a function of injected current produced a bell-shaped curve, and this relationship was essential to the transition of the f–I curve. In conclusion, our study confirms the importance of gAHP to repetitive firing and presents a novel explanation for the piecewise linear f–I curve of motoneurons." @default.
• W2079646310 created "2016-06-24" @default.
• W2079646310 creator A5052528832 @default.
• W2079646310 creator A5083831995 @default.
• W2079646310 date "2007-02-01" @default.
• W2079646310 modified "2023-10-09" @default.
• W2079646310 title "Repetitive firing of a model motoneuron: Inhibitory effect of a Ca2+-activated potassium conductance on the slope of the frequency–current relationship" @default.
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• W2079646310 doi "https://doi.org/10.1016/j.neures.2006.10.012" @default.
• W2079646310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17141906" @default.
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