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• W2079652945 endingPage "38" @default.
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• W2079652945 abstract "The main function of secretory IgA is to exert immune exclusion; that is, by intimate cooperation with innate non-specific defence mechanisms, it dampens down penetration of soluble antigens and inhibits epithelial colonisation of bacteria and viruses. Secretory IgM may exert a similar protective function in the gut as its local synthesis sometimes is markedly increased, especially in selective IgA deficiency. IgG should not be considered a secretory immunoglobulin because its external translocation depends on passive intercellular diffusion. By activating complement, antibodies of this isotype may cause increased mucosal permeability and tissue damage. IgG may thus contribute to persistent immunopathology in mucosal lesions. The same is true for IgE antibodies which, in atopic individuals, may be carried into the gut mucosa by mast cells and cause their degranulation with histamine release. Secretory IgA and secretory IgM are the products of two cell types: plasma cells synthesise IgA dimers and IgM pentamers which, by non-covalent association, become complexed with the secretory component (SC) which is synthesized by serous-type glandular cells. The adsorption of the Ig polymers to the SC-expressing epithelial cells depends on J chain-determined binding sites. This fact gives biological significance to the striking J chain expression shown by mucosal immunocytes regardless of the Ig class they produce. The immunocytes populating the gut mucosa apparently belong to relatively early memory B cell clones. The obvious functional goal of J chain expression at this stage of clonal differentiation is local generation of SC-binding IgA and IgM polymers. In various gut diseases, altered immune regulation results in a disproportionately increased number of J chain-negative IgG-producing cells in the mucosa. Such altered immunological homeostasis may contribute to perpetuation of inflammatory bowel diseases." @default.
• W2079652945 created "2016-06-24" @default.
• W2079652945 creator A5002610153 @default.
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• W2079652945 creator A5074691097 @default.
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• W2079652945 creator A5076144753 @default.
• W2079652945 date "1985-01-01" @default.
• W2079652945 modified "2023-09-27" @default.
• W2079652945 title "The Human Gastrointestinal Secretory Immune System in Health and Disease" @default.
• W2079652945 cites W1487903265 @default.
• W2079652945 cites W1601485168 @default.
• W2079652945 cites W162893544 @default.
• W2079652945 cites W1629017437 @default.
• W2079652945 cites W1786228688 @default.
• W2079652945 cites W19303070 @default.
• W2079652945 cites W1964786677 @default.
• W2079652945 cites W1974129677 @default.
• W2079652945 cites W1975207936 @default.
• W2079652945 cites W1975223975 @default.
• W2079652945 cites W1976715149 @default.
• W2079652945 cites W1980304376 @default.
• W2079652945 cites W1981178699 @default.
• W2079652945 cites W1984004823 @default.
• W2079652945 cites W1986004077 @default.
• W2079652945 cites W1987612820 @default.
• W2079652945 cites W1987786847 @default.
• W2079652945 cites W1994907872 @default.
• W2079652945 cites W1995301762 @default.
• W2079652945 cites W1996149638 @default.
• W2079652945 cites W1996271767 @default.
• W2079652945 cites W1998896820 @default.
• W2079652945 cites W1999228816 @default.
• W2079652945 cites W2001401484 @default.
• W2079652945 cites W2002902455 @default.
• W2079652945 cites W2008014387 @default.
• W2079652945 cites W2009636032 @default.
• W2079652945 cites W2014964931 @default.
• W2079652945 cites W2015042073 @default.
• W2079652945 cites W2020757815 @default.
• W2079652945 cites W2024593715 @default.
• W2079652945 cites W2025584833 @default.
• W2079652945 cites W2026256868 @default.
• W2079652945 cites W2028595928 @default.
• W2079652945 cites W2031357360 @default.
• W2079652945 cites W2032867820 @default.
• W2079652945 cites W2041028403 @default.
• W2079652945 cites W2041125433 @default.
• W2079652945 cites W2043312595 @default.
• W2079652945 cites W2044764664 @default.
• W2079652945 cites W2045759245 @default.
• W2079652945 cites W2047259779 @default.
• W2079652945 cites W2049366733 @default.
• W2079652945 cites W2053259369 @default.
• W2079652945 cites W2053278781 @default.
• W2079652945 cites W2053403899 @default.
• W2079652945 cites W2061751649 @default.
• W2079652945 cites W2061867498 @default.
• W2079652945 cites W2063191806 @default.
• W2079652945 cites W2064111638 @default.
• W2079652945 cites W2064754891 @default.
• W2079652945 cites W2065150962 @default.
• W2079652945 cites W2069020561 @default.
• W2079652945 cites W2069725651 @default.
• W2079652945 cites W2070834379 @default.
• W2079652945 cites W2073913157 @default.
• W2079652945 cites W2074001050 @default.
• W2079652945 cites W2076391750 @default.
• W2079652945 cites W2077058201 @default.
• W2079652945 cites W2078524828 @default.
• W2079652945 cites W2079869883 @default.
• W2079652945 cites W2081357241 @default.
• W2079652945 cites W2084140779 @default.
• W2079652945 cites W2085567717 @default.
• W2079652945 cites W2088814695 @default.
• W2079652945 cites W2089029668 @default.
• W2079652945 cites W2090969370 @default.
• W2079652945 cites W2091094220 @default.
• W2079652945 cites W2094517453 @default.
• W2079652945 cites W2097814298 @default.
• W2079652945 cites W2104991162 @default.
• W2079652945 cites W2110901069 @default.
• W2079652945 cites W2112848473 @default.
• W2079652945 cites W2138489941 @default.
• W2079652945 cites W2143148639 @default.
• W2079652945 cites W2148945107 @default.
• W2079652945 cites W2158076359 @default.
• W2079652945 cites W2160851928 @default.
• W2079652945 cites W2164942430 @default.
• W2079652945 cites W2166476896 @default.
• W2079652945 cites W2171781129 @default.
• W2079652945 cites W2174214567 @default.
• W2079652945 cites W2256353166 @default.
• W2079652945 cites W2314963017 @default.
• W2079652945 cites W2338393714 @default.
• W2079652945 cites W2404291649 @default.
• W2079652945 cites W2406239978 @default.

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