Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079656901> ?p ?o ?g. }
- W2079656901 abstract "Significance Microbially produced aliphatic alcohols are important biocommodities but exert toxic effects on cells. Understanding the mechanisms by which these alcohols inhibit microbial growth and generate resistant microbes will provide insight into microbial physiology and improve prospects for microbial biotechnology and biofuel production. We find that Escherichia coli ribosomes and RNA polymerase are mechanistically affected by ethanol, identifying the ribosome decoding center as a likely target of ethanol-mediated conformational disruption and showing that ethanol inhibits transcript elongation via direct effects on RNA polymerase. Our findings provide conceptual frameworks for the study of ethanol toxicity in microbes and for the engineering of ethanol tolerance that may be extensible to other microbes and to other short-chain alcohols." @default.
- W2079656901 created "2016-06-24" @default.
- W2079656901 creator A5010325555 @default.
- W2079656901 creator A5014512407 @default.
- W2079656901 creator A5019032783 @default.
- W2079656901 creator A5019665472 @default.
- W2079656901 creator A5019804972 @default.
- W2079656901 creator A5021667016 @default.
- W2079656901 creator A5030809311 @default.
- W2079656901 creator A5033315719 @default.
- W2079656901 creator A5049472174 @default.
- W2079656901 creator A5063330165 @default.
- W2079656901 creator A5063353715 @default.
- W2079656901 creator A5085149040 @default.
- W2079656901 creator A5091560006 @default.
- W2079656901 date "2014-06-09" @default.
- W2079656901 modified "2023-10-11" @default.
- W2079656901 title "Correcting direct effects of ethanol on translation and transcription machinery confers ethanol tolerance in bacteria" @default.
- W2079656901 cites W1530750782 @default.
- W2079656901 cites W1551816574 @default.
- W2079656901 cites W1569973595 @default.
- W2079656901 cites W1573477696 @default.
- W2079656901 cites W1574701848 @default.
- W2079656901 cites W1579065337 @default.
- W2079656901 cites W1595347220 @default.
- W2079656901 cites W1781531090 @default.
- W2079656901 cites W1910622708 @default.
- W2079656901 cites W1964508335 @default.
- W2079656901 cites W1971465234 @default.
- W2079656901 cites W1972497570 @default.
- W2079656901 cites W1973851828 @default.
- W2079656901 cites W1977551917 @default.
- W2079656901 cites W1977843995 @default.
- W2079656901 cites W1979360127 @default.
- W2079656901 cites W1982486868 @default.
- W2079656901 cites W1986842298 @default.
- W2079656901 cites W1990868144 @default.
- W2079656901 cites W1991220371 @default.
- W2079656901 cites W1992094275 @default.
- W2079656901 cites W2000427711 @default.
- W2079656901 cites W2007493979 @default.
- W2079656901 cites W2009329529 @default.
- W2079656901 cites W2011375533 @default.
- W2079656901 cites W2011753511 @default.
- W2079656901 cites W2012681204 @default.
- W2079656901 cites W2015088216 @default.
- W2079656901 cites W2015169267 @default.
- W2079656901 cites W2015414585 @default.
- W2079656901 cites W2016577330 @default.
- W2079656901 cites W2018166918 @default.
- W2079656901 cites W2023677017 @default.
- W2079656901 cites W2038186289 @default.
- W2079656901 cites W2041495974 @default.
- W2079656901 cites W2046404781 @default.
- W2079656901 cites W2048253719 @default.
- W2079656901 cites W2048600319 @default.
- W2079656901 cites W2049738084 @default.
- W2079656901 cites W2050079896 @default.
- W2079656901 cites W2055157975 @default.
- W2079656901 cites W2058141676 @default.
- W2079656901 cites W2058955390 @default.
- W2079656901 cites W2062570315 @default.
- W2079656901 cites W2070283475 @default.
- W2079656901 cites W2074484062 @default.
- W2079656901 cites W2074910098 @default.
- W2079656901 cites W2076592452 @default.
- W2079656901 cites W2079517684 @default.
- W2079656901 cites W2080537888 @default.
- W2079656901 cites W2080931263 @default.
- W2079656901 cites W2082140226 @default.
- W2079656901 cites W2085829432 @default.
- W2079656901 cites W2089853650 @default.
- W2079656901 cites W2090882232 @default.
- W2079656901 cites W2092530456 @default.
- W2079656901 cites W2093122332 @default.
- W2079656901 cites W2102154042 @default.
- W2079656901 cites W2103441770 @default.
- W2079656901 cites W2108926259 @default.
- W2079656901 cites W2109918485 @default.
- W2079656901 cites W2111967267 @default.
- W2079656901 cites W2115407301 @default.
- W2079656901 cites W2119980551 @default.
- W2079656901 cites W2120315186 @default.
- W2079656901 cites W2122649909 @default.
- W2079656901 cites W2129016585 @default.
- W2079656901 cites W2130714527 @default.
- W2079656901 cites W2134153749 @default.
- W2079656901 cites W2136067498 @default.
- W2079656901 cites W2136305830 @default.
- W2079656901 cites W2138611595 @default.
- W2079656901 cites W2141997506 @default.
- W2079656901 cites W2144455805 @default.
- W2079656901 cites W2146802614 @default.
- W2079656901 cites W2147787167 @default.
- W2079656901 cites W2157547677 @default.
- W2079656901 cites W2161161201 @default.
- W2079656901 cites W2164942155 @default.
- W2079656901 cites W2166157766 @default.
- W2079656901 cites W4255521514 @default.
- W2079656901 doi "https://doi.org/10.1073/pnas.1401853111" @default.