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• W2079657863 abstract "2-Phenyl-1, 2-benzisoselenazol-3-(2H)one (ebselen), a nontoxic seleno-organic compound, exhibits anti-inflammatory activity through the inhibition of many enzymes involved in inflammation. In view of the role played by histamine in the pathophysiology of inflammation, we looked at the effect of ebselen on histamine secretion by rat peritoneal mast cells. It inhibited compound 48/80-induced histamine release in a concentration-dependent manner. Half-maximal and maximal (100%) inhibitory response occurred at 5.10−7M and 10−5M, respectively. In contrast, ebselen was without any effect on histamine release induced immunologically. Prevention of the inhibitory effect of ebselen by GSH suggests that it interacts with critical thiols involved in the compound 48/80 activation pathway." @default.
• W2079657863 created "2016-06-24" @default.
• W2079657863 creator A5045849746 @default.
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• W2079657863 date "1998-12-01" @default.
• W2079657863 modified "2023-09-25" @default.
• W2079657863 title "Differential effect of ebselen on compound 48/80- and anti-IgE-induced histamine release from rat peritoneal mast cells" @default.
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• W2079657863 doi "https://doi.org/10.1016/s0006-2952(98)00252-4" @default.
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