Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079661961> ?p ?o ?g. }
- W2079661961 endingPage "2920" @default.
- W2079661961 startingPage "2915" @default.
- W2079661961 abstract "Abstract Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by bone marrow failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). Eight FA proteins associate in a nuclear core complex to monoubiquitinate FANCD2/FANCI in response to DNA damage. Additional functions have been described for some of the core complex proteins; however, in vivo genetic proof has been lacking. Here we show that double-mutant Fancc−/−;Fancg−/− mice develop spontaneous hematologic sequelae including bone marrow failure, AML, MDS and complex random chromosomal abnormalities that the single-mutant mice do not. This genetic model provides evidence for unique core complex protein function independent of their ability to monoubiquitinate FANCD2/FANCI. Importantly, this model closely recapitulates the phenotypes found in FA patients and may be useful as a preclinical platform to evaluate the molecular pathogenesis of spontaneous bone marrow failure, MDS and AML in FA." @default.
- W2079661961 created "2016-06-24" @default.
- W2079661961 creator A5010098535 @default.
- W2079661961 creator A5014320408 @default.
- W2079661961 creator A5015512950 @default.
- W2079661961 creator A5017322730 @default.
- W2079661961 creator A5022527850 @default.
- W2079661961 creator A5033631341 @default.
- W2079661961 creator A5033769456 @default.
- W2079661961 creator A5037453366 @default.
- W2079661961 creator A5069249031 @default.
- W2079661961 creator A5071651772 @default.
- W2079661961 creator A5073709188 @default.
- W2079661961 creator A5078320327 @default.
- W2079661961 creator A5082415828 @default.
- W2079661961 creator A5083057990 @default.
- W2079661961 creator A5086286601 @default.
- W2079661961 creator A5089543020 @default.
- W2079661961 date "2010-10-21" @default.
- W2079661961 modified "2023-10-02" @default.
- W2079661961 title "Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia" @default.
- W2079661961 cites W12283502 @default.
- W2079661961 cites W1549538719 @default.
- W2079661961 cites W1968633443 @default.
- W2079661961 cites W1971408707 @default.
- W2079661961 cites W1972346929 @default.
- W2079661961 cites W1980676055 @default.
- W2079661961 cites W1982609314 @default.
- W2079661961 cites W1986890123 @default.
- W2079661961 cites W1991591616 @default.
- W2079661961 cites W1991841649 @default.
- W2079661961 cites W2000067413 @default.
- W2079661961 cites W2003058744 @default.
- W2079661961 cites W2004264651 @default.
- W2079661961 cites W2024974524 @default.
- W2079661961 cites W2027312693 @default.
- W2079661961 cites W2031746309 @default.
- W2079661961 cites W2033414820 @default.
- W2079661961 cites W2036716410 @default.
- W2079661961 cites W2038012621 @default.
- W2079661961 cites W2044130461 @default.
- W2079661961 cites W2048446461 @default.
- W2079661961 cites W2055611673 @default.
- W2079661961 cites W2061914986 @default.
- W2079661961 cites W2063483333 @default.
- W2079661961 cites W2071782656 @default.
- W2079661961 cites W2073715782 @default.
- W2079661961 cites W2084310601 @default.
- W2079661961 cites W2085326817 @default.
- W2079661961 cites W2087505934 @default.
- W2079661961 cites W2087967916 @default.
- W2079661961 cites W2099023168 @default.
- W2079661961 cites W2103988356 @default.
- W2079661961 cites W2104441503 @default.
- W2079661961 cites W2106335498 @default.
- W2079661961 cites W2111017229 @default.
- W2079661961 cites W2112664493 @default.
- W2079661961 cites W2114907977 @default.
- W2079661961 cites W2117511932 @default.
- W2079661961 cites W2128700722 @default.
- W2079661961 cites W2138543689 @default.
- W2079661961 cites W2147822034 @default.
- W2079661961 cites W2153314251 @default.
- W2079661961 cites W2158800860 @default.
- W2079661961 cites W2213177567 @default.
- W2079661961 cites W3117462546 @default.
- W2079661961 cites W4232381495 @default.
- W2079661961 cites W4241725533 @default.
- W2079661961 cites W4302212409 @default.
- W2079661961 doi "https://doi.org/10.1182/blood-2009-08-240747" @default.
- W2079661961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2974601" @default.
- W2079661961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20606166" @default.
- W2079661961 hasPublicationYear "2010" @default.
- W2079661961 type Work @default.
- W2079661961 sameAs 2079661961 @default.
- W2079661961 citedByCount "50" @default.
- W2079661961 countsByYear W20796619612012 @default.
- W2079661961 countsByYear W20796619612013 @default.
- W2079661961 countsByYear W20796619612014 @default.
- W2079661961 countsByYear W20796619612015 @default.
- W2079661961 countsByYear W20796619612016 @default.
- W2079661961 countsByYear W20796619612017 @default.
- W2079661961 countsByYear W20796619612018 @default.
- W2079661961 countsByYear W20796619612019 @default.
- W2079661961 countsByYear W20796619612020 @default.
- W2079661961 countsByYear W20796619612021 @default.
- W2079661961 countsByYear W20796619612022 @default.
- W2079661961 countsByYear W20796619612023 @default.
- W2079661961 crossrefType "journal-article" @default.
- W2079661961 hasAuthorship W2079661961A5010098535 @default.
- W2079661961 hasAuthorship W2079661961A5014320408 @default.
- W2079661961 hasAuthorship W2079661961A5015512950 @default.
- W2079661961 hasAuthorship W2079661961A5017322730 @default.
- W2079661961 hasAuthorship W2079661961A5022527850 @default.
- W2079661961 hasAuthorship W2079661961A5033631341 @default.
- W2079661961 hasAuthorship W2079661961A5033769456 @default.
- W2079661961 hasAuthorship W2079661961A5037453366 @default.
- W2079661961 hasAuthorship W2079661961A5069249031 @default.