FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079662202> ?p ?o ?g. }

• W2079662202 endingPage "1347" @default.
• W2079662202 startingPage "1340" @default.
• W2079662202 abstract "Abstract: An involvement of excitatory amino acid (EAA) transmitter–receptor interactions in the development of hypoglycemia-induced neuronal damage has been suggested. We report here on the binding to EAA receptors in the rat caudate nucleus and cerebral cortex, during and following severe insulin-induced hypoglycemia with an isoelectric EEG of 10 or 30 min duration. The binding of α[3H]amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ([3H]AMPA) to quisqualate receptors, [3H]kainic acid (KA) to kainate receptors, and [3H]glutamate to N-methyl-D-aspartate (NMDA)-sensitive sites was determined by quantitative autoradiography. During EEG isoelectricity, AMPA binding was reduced by approximately 40%, which could represent quisqualate receptor desensitization. One hour following glucose-induced recovery, AMPA binding was no longer different from control level. As the recovery period was prolonged to 1 or 4 weeks, AMPA binding decreased. The decrease was more pronounced in the dorsolateral than in the ventromedial part of the striatum. This correlates with the distribution of neuronal damage, and probably reflects loss of receptor binding sites due to cell death. During the period of EEG silence there was a tendency toward an increase in NMDA displaceable glutamate binding. Following 4 weeks of recovery, binding to NMDA receptors was significantly decreased. Glutamate binding to NMDA-sensitive sites was remarkably resistant to neuronal necrosis and was not significantly different from control values in the dorsolateral caudate 1 week following the hypoglycemic coma. No changes in KA binding were found until 1 week posthypoglycemia, when a significant reduction in binding was noted in the lateral striatum. Two weeks following partial unilateral cortical ablation, binding to NMDA receptors in the striatum decreased in the lesioned hemisphere in control animals and remained significantly lower than in the contralateral hemisphere during EEG isoelectricity. In contrast, no hemispheric differences in AMPA binding were observed. The lack of desensitization of NMDA receptors during EEG isoelectricity and their relative resistance to neuronal necrosis could be of significance for the development of hypoglycemic neuronal damage." @default.
• W2079662202 created "2016-06-24" @default.
• W2079662202 creator A5002601515 @default.
• W2079662202 creator A5071331742 @default.
• W2079662202 date "1989-05-01" @default.
• W2079662202 modified "2023-10-18" @default.
• W2079662202 title "Changes in Excitatory Amino Acid Receptor Binding in the Intact and Decorticated Rat Neostriatum Following Insulin-Induced Hypoglycemia" @default.
• W2079662202 cites W115726695 @default.
• W2079662202 cites W1910864442 @default.
• W2079662202 cites W1970377013 @default.
• W2079662202 cites W1987349869 @default.
• W2079662202 cites W1991068505 @default.
• W2079662202 cites W1998164097 @default.
• W2079662202 cites W2001500956 @default.
• W2079662202 cites W2002433566 @default.
• W2079662202 cites W2013693658 @default.
• W2079662202 cites W2028995833 @default.
• W2079662202 cites W2032226880 @default.
• W2079662202 cites W2032261379 @default.
• W2079662202 cites W2035750459 @default.
• W2079662202 cites W2037772094 @default.
• W2079662202 cites W2038862011 @default.
• W2079662202 cites W2051395367 @default.
• W2079662202 cites W2052085932 @default.
• W2079662202 cites W2052352776 @default.
• W2079662202 cites W2053235413 @default.
• W2079662202 cites W2058148599 @default.
• W2079662202 cites W2075057355 @default.
• W2079662202 cites W2077450279 @default.
• W2079662202 cites W2082671275 @default.
• W2079662202 cites W2132219303 @default.
• W2079662202 cites W2147687590 @default.
• W2079662202 cites W2153823370 @default.
• W2079662202 cites W2180941170 @default.
• W2079662202 cites W2471761172 @default.
• W2079662202 cites W266187418 @default.
• W2079662202 cites W3010224280 @default.
• W2079662202 cites W3164251665 @default.
• W2079662202 doi "https://doi.org/10.1111/j.1471-4159.1989.tb09177.x" @default.
• W2079662202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2565371" @default.
• W2079662202 hasPublicationYear "1989" @default.
• W2079662202 type Work @default.
• W2079662202 sameAs 2079662202 @default.
• W2079662202 citedByCount "10" @default.
• W2079662202 countsByYear W20796622022014 @default.
• W2079662202 crossrefType "journal-article" @default.
• W2079662202 hasAuthorship W2079662202A5002601515 @default.
• W2079662202 hasAuthorship W2079662202A5071331742 @default.
• W2079662202 hasConcept C126322002 @default.
• W2079662202 hasConcept C134018914 @default.
• W2079662202 hasConcept C160268369 @default.
• W2079662202 hasConcept C169760540 @default.
• W2079662202 hasConcept C170493617 @default.
• W2079662202 hasConcept C185592680 @default.
• W2079662202 hasConcept C189184402 @default.
• W2079662202 hasConcept C2776108384 @default.
• W2079662202 hasConcept C61174792 @default.
• W2079662202 hasConcept C67018056 @default.
• W2079662202 hasConcept C71924100 @default.
• W2079662202 hasConcept C86803240 @default.
• W2079662202 hasConceptScore W2079662202C126322002 @default.
• W2079662202 hasConceptScore W2079662202C134018914 @default.
• W2079662202 hasConceptScore W2079662202C160268369 @default.
• W2079662202 hasConceptScore W2079662202C169760540 @default.
• W2079662202 hasConceptScore W2079662202C170493617 @default.
• W2079662202 hasConceptScore W2079662202C185592680 @default.
• W2079662202 hasConceptScore W2079662202C189184402 @default.
• W2079662202 hasConceptScore W2079662202C2776108384 @default.
• W2079662202 hasConceptScore W2079662202C61174792 @default.
• W2079662202 hasConceptScore W2079662202C67018056 @default.
• W2079662202 hasConceptScore W2079662202C71924100 @default.
• W2079662202 hasConceptScore W2079662202C86803240 @default.
• W2079662202 hasIssue "5" @default.
• W2079662202 hasLocation W20796622021 @default.
• W2079662202 hasLocation W20796622022 @default.
• W2079662202 hasOpenAccess W2079662202 @default.
• W2079662202 hasPrimaryLocation W20796622021 @default.
• W2079662202 hasRelatedWork W1972728329 @default.
• W2079662202 hasRelatedWork W1998846538 @default.
• W2079662202 hasRelatedWork W1999315981 @default.
• W2079662202 hasRelatedWork W2023646123 @default.
• W2079662202 hasRelatedWork W2025676835 @default.
• W2079662202 hasRelatedWork W2080869223 @default.
• W2079662202 hasRelatedWork W2087901892 @default.
• W2079662202 hasRelatedWork W2089892818 @default.
• W2079662202 hasRelatedWork W2102027630 @default.
• W2079662202 hasRelatedWork W2127692778 @default.
• W2079662202 hasVolume "52" @default.
• W2079662202 isParatext "false" @default.
• W2079662202 isRetracted "false" @default.
• W2079662202 magId "2079662202" @default.
• W2079662202 workType "article" @default.