FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079662405> ?p ?o ?g. }

• W2079662405 endingPage "21" @default.
• W2079662405 startingPage "17" @default.
• W2079662405 abstract "Checkpoint genes, activated in response to DNA damage and other stresses, are frequently targeted for alteration in cancer. Checkpoint kinase 2 (CHK2, CDS1, RAD53) is activated by ataxia telangiectasia mutated (ATM) in response to gamma irradiation. Activated CHK2 stabilizes TP53, and acts on other cell cycle and stress regulators. These findings place CHK2 in the middle of a pathway frequently targeted in cancer. Because of this, and the observation that CHK2 mutations are inherited in some Li-Fraumeni cancer syndrome families, we decided to examine the role of CHK2 mutations in sporadic cancers. Exploiting the genomic sequence of chromosome 22, we looked for mutations in the exons and intron junctions of the CHK2 gene in DNA samples from 170 patients (57 osteosarcomas, 25 other sarcomas, 35 nonsmall-cell lung, 20 ovarian, and 33 breast cancers). Missense mutations affecting the forkhead and kinase domains were detected in four osteosarcomas and in one ovarian and one lung cancer. These findings of CHK2 gene mutations are consistent with osteosarcoma being a defining tumor of Li-Fraumeni syndrome. The occurrence of CHK2 mutations in sporadic cancers emphasizes the importance of the stress pathway which includes TP53." @default.
• W2079662405 created "2016-06-24" @default.
• W2079662405 creator A5001753251 @default.
• W2079662405 creator A5013196637 @default.
• W2079662405 creator A5022616874 @default.
• W2079662405 creator A5041902596 @default.
• W2079662405 creator A5049465924 @default.
• W2079662405 creator A5051889915 @default.
• W2079662405 creator A5075269340 @default.
• W2079662405 creator A5081468712 @default.
• W2079662405 creator A5082903377 @default.
• W2079662405 date "2001-12-07" @default.
• W2079662405 modified "2023-10-11" @default.
• W2079662405 title "Mutations of theCHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors" @default.
• W2079662405 cites W1488719611 @default.
• W2079662405 cites W1493976230 @default.
• W2079662405 cites W1494182669 @default.
• W2079662405 cites W1971536842 @default.
• W2079662405 cites W1988876917 @default.
• W2079662405 cites W2014195831 @default.
• W2079662405 cites W2028044172 @default.
• W2079662405 cites W2034317592 @default.
• W2079662405 cites W2038612913 @default.
• W2079662405 cites W2042848097 @default.
• W2079662405 cites W2043136696 @default.
• W2079662405 cites W2057965100 @default.
• W2079662405 cites W2074026594 @default.
• W2079662405 cites W2083728258 @default.
• W2079662405 cites W2121446363 @default.
• W2079662405 cites W2128804130 @default.
• W2079662405 cites W2131833681 @default.
• W2079662405 cites W2146342437 @default.
• W2079662405 cites W2158505124 @default.
• W2079662405 cites W2159040452 @default.
• W2079662405 cites W2166548889 @default.
• W2079662405 cites W2325060315 @default.
• W2079662405 cites W2949977409 @default.
• W2079662405 doi "https://doi.org/10.1002/gcc.1207" @default.
• W2079662405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11746983" @default.
• W2079662405 hasPublicationYear "2001" @default.
• W2079662405 type Work @default.
• W2079662405 sameAs 2079662405 @default.
• W2079662405 citedByCount "97" @default.
• W2079662405 countsByYear W20796624052012 @default.
• W2079662405 countsByYear W20796624052013 @default.
• W2079662405 countsByYear W20796624052014 @default.
• W2079662405 countsByYear W20796624052015 @default.
• W2079662405 countsByYear W20796624052017 @default.
• W2079662405 countsByYear W20796624052018 @default.
• W2079662405 countsByYear W20796624052021 @default.
• W2079662405 countsByYear W20796624052022 @default.
• W2079662405 countsByYear W20796624052023 @default.
• W2079662405 crossrefType "journal-article" @default.
• W2079662405 hasAuthorship W2079662405A5001753251 @default.
• W2079662405 hasAuthorship W2079662405A5013196637 @default.
• W2079662405 hasAuthorship W2079662405A5022616874 @default.
• W2079662405 hasAuthorship W2079662405A5041902596 @default.
• W2079662405 hasAuthorship W2079662405A5049465924 @default.
• W2079662405 hasAuthorship W2079662405A5051889915 @default.
• W2079662405 hasAuthorship W2079662405A5075269340 @default.
• W2079662405 hasAuthorship W2079662405A5081468712 @default.
• W2079662405 hasAuthorship W2079662405A5082903377 @default.
• W2079662405 hasConcept C104317684 @default.
• W2079662405 hasConcept C105696609 @default.
• W2079662405 hasConcept C121608353 @default.
• W2079662405 hasConcept C13514818 @default.
• W2079662405 hasConcept C143425029 @default.
• W2079662405 hasConcept C2777983448 @default.
• W2079662405 hasConcept C2778264664 @default.
• W2079662405 hasConcept C2780427987 @default.
• W2079662405 hasConcept C2781187634 @default.
• W2079662405 hasConcept C2910325170 @default.
• W2079662405 hasConcept C29537977 @default.
• W2079662405 hasConcept C36823959 @default.
• W2079662405 hasConcept C501734568 @default.
• W2079662405 hasConcept C502942594 @default.
• W2079662405 hasConcept C54355233 @default.
• W2079662405 hasConcept C552990157 @default.
• W2079662405 hasConcept C555283112 @default.
• W2079662405 hasConcept C86803240 @default.
• W2079662405 hasConceptScore W2079662405C104317684 @default.
• W2079662405 hasConceptScore W2079662405C105696609 @default.
• W2079662405 hasConceptScore W2079662405C121608353 @default.
• W2079662405 hasConceptScore W2079662405C13514818 @default.
• W2079662405 hasConceptScore W2079662405C143425029 @default.
• W2079662405 hasConceptScore W2079662405C2777983448 @default.
• W2079662405 hasConceptScore W2079662405C2778264664 @default.
• W2079662405 hasConceptScore W2079662405C2780427987 @default.
• W2079662405 hasConceptScore W2079662405C2781187634 @default.
• W2079662405 hasConceptScore W2079662405C2910325170 @default.
• W2079662405 hasConceptScore W2079662405C29537977 @default.
• W2079662405 hasConceptScore W2079662405C36823959 @default.
• W2079662405 hasConceptScore W2079662405C501734568 @default.
• W2079662405 hasConceptScore W2079662405C502942594 @default.
• W2079662405 hasConceptScore W2079662405C54355233 @default.
• W2079662405 hasConceptScore W2079662405C552990157 @default.
• W2079662405 hasConceptScore W2079662405C555283112 @default.
• W2079662405 hasConceptScore W2079662405C86803240 @default.

• next