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• W2079662634 endingPage "417" @default.
• W2079662634 startingPage "413" @default.
• W2079662634 abstract "The role of astrocytic gap junctions in ischemia remains controversial. Several studies support that astrocytic gap junctions play a role in the spread of hypoxic injury, while other reports have demonstrated that blocking astrocytic gap junctions increases neuronal death. Using a stroke model on animals in which the astrocytic gap junction protein connexin43 (Cx43) was compromised, we explored the neuroprotective role of astrocytic gap junctions. A focal brain stroke was performed on heterozygous Cx43 null [Cx43(+/-)] mice, wild type [Cx43(+/+)] mice, astrocyte-directed Cx43 deficient [Cx43(fl/ fl)/hGFAP-cre] mice (here designated as Cre(+) mice), and their corresponding controls [Cx43(fl/fl)] (here designated as Cre(-) mice). Four days following stroke, ischemic lesions were measured for size and analyzed immunohistochemically. Stroke volume was significantly larger in Cx43(+/-) and Cre(+) mice compared to Cx43(+/+) and Cre(-) mice, respectively. Apoptosis as detected by TUNEL labeling and caspase-3 immunostaining was amplified in Cx43(+/-) and Cre(+) mice compared to their control groups. Furthermore, increased inflammation as characterized by the immunohistochemical staining of the microglial marker CD11b was observed in the Cre(+) mice penumbra. Astrocytic gap junctions may reduce apoptosis and inflammation in the penumbra following ischemic insult, suggesting that coupled astrocytes fulfill a neuroprotective role under ischemic stroke conditions." @default.
• W2079662634 created "2016-06-24" @default.
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• W2079662634 date "2003-01-01" @default.
• W2079662634 modified "2023-10-17" @default.
• W2079662634 title "Neuroprotective Role of Astrocytic Gap Junctions in Ischemic Stroke" @default.
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• W2079662634 doi "https://doi.org/10.1080/cac.10.4-6.413.417" @default.
• W2079662634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14681050" @default.
• W2079662634 hasPublicationYear "2003" @default.
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