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- W2079662756 abstract "Pharmacological approaches have defined the epsilon receptor as a β-endorphin-preferring opioid receptor, described in rat vas deferens and in brain of several species. Only three opioid receptors—mu, delta and kappa—have been cloned and the existence of this additional subtype as a distinct protein remains controversial. Recently, the mouse brain epsilon receptor was detected in a G protein activation assay, as mediating residual β-endorphin activity following pharmacological blockade of mu, delta and kappa receptors. To clarify whether this site is independent from mu, delta and kappa receptors, we performed β-endorphin-induced [35S]GTPγS binding using mice lacking these three receptors (triple knockout mice). We tested both pons–medulla and whole brain preparations. β-Endorphin strongly stimulated [35S]GTPγS binding in wild-type membranes but had no detectable effect in membranes from triple knockout mice. We conclude that the brain epsilon site involves mu, delta and/or kappa receptors, possibly coupled to nonclassical G proteins." @default.
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- W2079662756 date "2004-05-01" @default.
- W2079662756 modified "2023-09-24" @default.
- W2079662756 title "No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse" @default.
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- W2079662756 doi "https://doi.org/10.1016/j.ejphar.2004.03.056" @default.
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