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- W2079664588 abstract "Frozen embryo transfer (FET) and donor oocyte recipient cycles (DRC) typically employ exogenous estrogen to prepare the endometrium. At ultrasound assessment, many patients have an endometrium considered too thin or of an inadequate pattern to expect typical pregnancy. Our objective was to evaluate the effect of gonadotropin stimulation on endometrial development in patients with history of poor endometrial development undergoing FET or donor cycles. Retrospective analysis. FET or DRC utilizing gonadotropins for endometrial development were compared to their own prior cycles treated with exogenous estrogen without gonadotropins. Women who underwent at least one FET or DRC with gonadotropin stimulation for endometrial preparation were identified from 2004-2012. Generalize estimating equations (GEE) were used to compare both continuous and dichotomous variables. This modeling accounted for nesting of multiple cycles contributed by one patient both for control and treatment cycle groups. 39 patients were included, totaling 63 treatment cycles utilizing gonadotropins and 105 control cycles. Control cycles had higher peak estradiol. Despite this, the treatment group had higher peak endometrial thickness (EMT), lower odds of cycle cancellation for poor endometrial development, and higher odds of live birth (Table 1). In GEE modeling, gonadotropin treatment had higher odds of live birth (OR 1.30, 95%CI 1.13-1.49).Tabled 1Table 1OutcomeControl Cycles (n=105)Gonadotropin Cycles (n=63)OR (95%CI)P valuePeak Estradiol2333930-1403 (1036-1770)<0.01Mean Endometrial Thickness7.1 ± 1.88.3 ± 2.71.2 (0.15-2.2)<0.001% Cancelled (poor endometrium)43.817.40.76 (0.65-0.89)<0.001% Live Birth6.733.31.31 (1.14-1.50)<0.001 Open table in a new tab This retrospective analysis suggests that some patients who have poor endometrial development from exogenous estrogen alone may benefit from exogenous gonadotropins in FET and DRC. This effect was not associated with estradiol concentration, suggesting potential benefit of endogenous estrogen or gonadotropin effect. The study design has potential bias due to regression to the mean, however, these data suggest this treatment should be evaluated in a prospective controlled fashion." @default.
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- W2079664588 date "2014-09-01" @default.
- W2079664588 modified "2023-09-28" @default.
- W2079664588 title "Exogenous gonadotropins for poor endometrial responders" @default.
- W2079664588 doi "https://doi.org/10.1016/j.fertnstert.2014.07.1006" @default.
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