Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079665797> ?p ?o ?g. }
- W2079665797 endingPage "483" @default.
- W2079665797 startingPage "469" @default.
- W2079665797 abstract "The dorsal regions of the midbrain and pons have been found to participate in sleep regulation. However, the physiological role of the ventral brainstem in sleep regulation remains unclear. We used N-methyl-d-aspartate-induced lesions of the ventral midbrain and pons to address this question. Unlike dorsal mesencephalic reticular formation lesions, which produce somnolence and electroencephalogram synchronization, we found that ventral midbrain lesions produce insomnia and hyperactivity. Marked increases in waking and decreases in slow wave sleep stage 1 (S1), stage 2 (S2) and rapid eye movement sleep were found immediately after the lesion. Sleep gradually increased, but never returned to baseline levels (baseline/month 1 post-lesion: waking, 30.6±4.58%/62.3±10.1%; S1, 5.1±0.74/3.9±1.91%; S2, 46.2±4.74%/23.1±5.47%; rapid eye movement sleep, 14.1±3.15%/7.2±5.42%). These changes are comparable in magnitude to those seen after basal forebrain lesions. Neuronal degeneration was found in the ventral rostral pons and midbrain, including the substantia nigra, ventral tegmental area, retrorubral nucleus, and ventral mesencephalic and rostroventral pontine reticular formation. We conclude that nuclei within the ventral mesencephalon and rostroventral pons play an important role in sleep regulation." @default.
- W2079665797 created "2016-06-24" @default.
- W2079665797 creator A5008027368 @default.
- W2079665797 creator A5033172430 @default.
- W2079665797 creator A5039691277 @default.
- W2079665797 creator A5059349729 @default.
- W2079665797 creator A5063747400 @default.
- W2079665797 creator A5066052652 @default.
- W2079665797 creator A5070736314 @default.
- W2079665797 date "1999-02-01" @default.
- W2079665797 modified "2023-10-18" @default.
- W2079665797 title "Neurotoxic N-methyl-d-aspartate lesion of the ventral midbrain and mesopontine junction alters sleep–wake organization" @default.
- W2079665797 cites W1238819995 @default.
- W2079665797 cites W145139182 @default.
- W2079665797 cites W1589605243 @default.
- W2079665797 cites W1658437126 @default.
- W2079665797 cites W1661140669 @default.
- W2079665797 cites W178191881 @default.
- W2079665797 cites W1972758977 @default.
- W2079665797 cites W1973729800 @default.
- W2079665797 cites W1973937621 @default.
- W2079665797 cites W1974949958 @default.
- W2079665797 cites W1977765232 @default.
- W2079665797 cites W1979355251 @default.
- W2079665797 cites W1980663017 @default.
- W2079665797 cites W1989056348 @default.
- W2079665797 cites W1993134393 @default.
- W2079665797 cites W1995433511 @default.
- W2079665797 cites W2002249230 @default.
- W2079665797 cites W2005292587 @default.
- W2079665797 cites W2006261379 @default.
- W2079665797 cites W2008095532 @default.
- W2079665797 cites W2016789240 @default.
- W2079665797 cites W2016799940 @default.
- W2079665797 cites W2017608248 @default.
- W2079665797 cites W2018523982 @default.
- W2079665797 cites W2021796356 @default.
- W2079665797 cites W2033580222 @default.
- W2079665797 cites W2034450065 @default.
- W2079665797 cites W2035197424 @default.
- W2079665797 cites W2035596237 @default.
- W2079665797 cites W2037015428 @default.
- W2079665797 cites W2039279998 @default.
- W2079665797 cites W2039907915 @default.
- W2079665797 cites W2043055848 @default.
- W2079665797 cites W2043515975 @default.
- W2079665797 cites W2046204676 @default.
- W2079665797 cites W2046227869 @default.
- W2079665797 cites W2055904512 @default.
- W2079665797 cites W2057259149 @default.
- W2079665797 cites W2058176748 @default.
- W2079665797 cites W2060583796 @default.
- W2079665797 cites W2061358325 @default.
- W2079665797 cites W2063744250 @default.
- W2079665797 cites W2065429215 @default.
- W2079665797 cites W2067032924 @default.
- W2079665797 cites W2067071952 @default.
- W2079665797 cites W2075236615 @default.
- W2079665797 cites W2076666702 @default.
- W2079665797 cites W2077244173 @default.
- W2079665797 cites W2077458491 @default.
- W2079665797 cites W2078964253 @default.
- W2079665797 cites W2081233133 @default.
- W2079665797 cites W2081555717 @default.
- W2079665797 cites W2088030762 @default.
- W2079665797 cites W2088415930 @default.
- W2079665797 cites W2091017278 @default.
- W2079665797 cites W2092626585 @default.
- W2079665797 cites W2094090855 @default.
- W2079665797 cites W2095939919 @default.
- W2079665797 cites W2107616890 @default.
- W2079665797 cites W2113895006 @default.
- W2079665797 cites W2124454245 @default.
- W2079665797 cites W2157747136 @default.
- W2079665797 cites W2158419872 @default.
- W2079665797 cites W2160003733 @default.
- W2079665797 cites W2168927918 @default.
- W2079665797 cites W2204053446 @default.
- W2079665797 cites W2270809559 @default.
- W2079665797 cites W2411046390 @default.
- W2079665797 cites W2418756859 @default.
- W2079665797 cites W2602498755 @default.
- W2079665797 cites W29869865 @default.
- W2079665797 cites W81777342 @default.
- W2079665797 doi "https://doi.org/10.1016/s0306-4522(98)00429-1" @default.
- W2079665797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10215152" @default.
- W2079665797 hasPublicationYear "1999" @default.
- W2079665797 type Work @default.
- W2079665797 sameAs 2079665797 @default.
- W2079665797 citedByCount "43" @default.
- W2079665797 countsByYear W20796657972012 @default.
- W2079665797 countsByYear W20796657972013 @default.
- W2079665797 countsByYear W20796657972014 @default.
- W2079665797 countsByYear W20796657972016 @default.
- W2079665797 countsByYear W20796657972017 @default.
- W2079665797 countsByYear W20796657972018 @default.
- W2079665797 countsByYear W20796657972019 @default.
- W2079665797 countsByYear W20796657972020 @default.