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- W2079666345 abstract "The final formulations of modern pharmaceutical protein products typically contain sugars or sugar alcohols as stabilizers. Migration of these sugars under the influence of an applied gravitational field during sedimentation velocity analytical ultracentrifugation (SV-AUC) produces dynamic density and viscosity gradients. If the formation of such gradients is not taken into account during data analysis, the capability of the SV-AUC technique to detect protein oligomers/aggregates may be dramatically impacted. In the example described here, the limit of quantitation (LOQ) of a simulated monoclonal antibody (mAb) dimer increases from 0.8% to 2.4% upon addition of 5% sorbitol to the formulation. This study uses simulated and experimental SV-AUC data to demonstrate the detrimental effect of dynamic gradients; it further explores how sophisticated data analysis techniques, including SEDFIT's inhomogeneous solvent options, may be used to mitigate the detection problems caused by the sedimentation of excipients." @default.
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- W2079666345 date "2009-01-01" @default.
- W2079666345 modified "2023-10-17" @default.
- W2079666345 title "Common Excipients Impair Detection of Protein Aggregates During Sedimentation Velocity Analytical Ultracentrifugation" @default.
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- W2079666345 doi "https://doi.org/10.1002/jps.21403" @default.
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