FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079667503> ?p ?o ?g. }

• W2079667503 endingPage "379" @default.
• W2079667503 startingPage "371" @default.
• W2079667503 abstract "Little is known about which genes mediate metastasis in bladder cancer, which accounts for much of the mortality of this disease. We used human bladder cancer cell lines to develop models of two clinically common metastatic sites, lung and liver, and evaluated their gene expression with respect to human tumor tissues. Parental cells were injected into either the murine spleen to generate liver metastases or tail vein to generate lung metastases with sequential progeny derived by re-injection and comparisons made of their organ-specific nature by crossed-site injections. Both genomic and transcriptomic analyses of organ-selected cell lines found salient differences and shared core metastatic profiles, which were then screened against gene expression data from human tumors. The expression levels of laminin V gamma 2 (LAMC2) contained in the core metastatic signature were increased as a function of human tumor stage, and its genomic location was in an area of gain as measured by comparative genomic hybridization. Using immunohistochemistry in a human bladder cancer tissue microarray, LAMC2 expression levels were associated with tumor grade, but inversely with nodal status. In contrast, in node-negative patients, LAMC2 expression was associated with visceral metastatic recurrence. In summary, LAMC2 is a novel biomarker of bladder cancer metastasis that reflects the propensity of cells to metastasize via either lymphatic or hematogenous routes." @default.
• W2079667503 created "2016-06-24" @default.
• W2079667503 creator A5001099941 @default.
• W2079667503 creator A5020183452 @default.
• W2079667503 creator A5024623701 @default.
• W2079667503 creator A5041630981 @default.
• W2079667503 creator A5050414062 @default.
• W2079667503 creator A5077087475 @default.
• W2079667503 creator A5087914830 @default.
• W2079667503 creator A5088212088 @default.
• W2079667503 date "2009-02-01" @default.
• W2079667503 modified "2023-10-18" @default.
• W2079667503 title "Profiling Bladder Cancer Organ Site-Specific Metastasis Identifies LAMC2 as a Novel Biomarker of Hematogenous Dissemination" @default.
• W2079667503 cites W1926637130 @default.
• W2079667503 cites W1966633872 @default.
• W2079667503 cites W1967251768 @default.
• W2079667503 cites W1978846041 @default.
• W2079667503 cites W1981562438 @default.
• W2079667503 cites W1984918063 @default.
• W2079667503 cites W1986471913 @default.
• W2079667503 cites W2000159364 @default.
• W2079667503 cites W2003313271 @default.
• W2079667503 cites W2010397777 @default.
• W2079667503 cites W2011191790 @default.
• W2079667503 cites W2013451756 @default.
• W2079667503 cites W2018561776 @default.
• W2079667503 cites W2023427658 @default.
• W2079667503 cites W2038099835 @default.
• W2079667503 cites W2040759573 @default.
• W2079667503 cites W2049515197 @default.
• W2079667503 cites W2054831639 @default.
• W2079667503 cites W2062409008 @default.
• W2079667503 cites W2081447858 @default.
• W2079667503 cites W2082829501 @default.
• W2079667503 cites W2082833890 @default.
• W2079667503 cites W2093921289 @default.
• W2079667503 cites W2100089932 @default.
• W2079667503 cites W2113500634 @default.
• W2079667503 cites W2153043355 @default.
• W2079667503 cites W2155348198 @default.
• W2079667503 cites W2156503775 @default.
• W2079667503 cites W2157215186 @default.
• W2079667503 cites W2387342675 @default.
• W2079667503 cites W2994933799 @default.
• W2079667503 doi "https://doi.org/10.2353/ajpath.2009.080538" @default.
• W2079667503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2630547" @default.
• W2079667503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19147813" @default.
• W2079667503 hasPublicationYear "2009" @default.
• W2079667503 type Work @default.
• W2079667503 sameAs 2079667503 @default.
• W2079667503 citedByCount "33" @default.
• W2079667503 countsByYear W20796675032012 @default.
• W2079667503 countsByYear W20796675032013 @default.
• W2079667503 countsByYear W20796675032014 @default.
• W2079667503 countsByYear W20796675032015 @default.
• W2079667503 countsByYear W20796675032016 @default.
• W2079667503 countsByYear W20796675032017 @default.
• W2079667503 countsByYear W20796675032018 @default.
• W2079667503 countsByYear W20796675032019 @default.
• W2079667503 countsByYear W20796675032020 @default.
• W2079667503 countsByYear W20796675032021 @default.
• W2079667503 countsByYear W20796675032022 @default.
• W2079667503 crossrefType "journal-article" @default.
• W2079667503 hasAuthorship W2079667503A5001099941 @default.
• W2079667503 hasAuthorship W2079667503A5020183452 @default.
• W2079667503 hasAuthorship W2079667503A5024623701 @default.
• W2079667503 hasAuthorship W2079667503A5041630981 @default.
• W2079667503 hasAuthorship W2079667503A5050414062 @default.
• W2079667503 hasAuthorship W2079667503A5077087475 @default.
• W2079667503 hasAuthorship W2079667503A5087914830 @default.
• W2079667503 hasAuthorship W2079667503A5088212088 @default.
• W2079667503 hasBestOaLocation W20796675031 @default.
• W2079667503 hasConcept C104317684 @default.
• W2079667503 hasConcept C121608353 @default.
• W2079667503 hasConcept C142724271 @default.
• W2079667503 hasConcept C150194340 @default.
• W2079667503 hasConcept C162317418 @default.
• W2079667503 hasConcept C181152851 @default.
• W2079667503 hasConcept C18431079 @default.
• W2079667503 hasConcept C204232928 @default.
• W2079667503 hasConcept C2779013556 @default.
• W2079667503 hasConcept C2780352672 @default.
• W2079667503 hasConcept C502942594 @default.
• W2079667503 hasConcept C54355233 @default.
• W2079667503 hasConcept C55493867 @default.
• W2079667503 hasConcept C71924100 @default.
• W2079667503 hasConcept C86803240 @default.
• W2079667503 hasConceptScore W2079667503C104317684 @default.
• W2079667503 hasConceptScore W2079667503C121608353 @default.
• W2079667503 hasConceptScore W2079667503C142724271 @default.
• W2079667503 hasConceptScore W2079667503C150194340 @default.
• W2079667503 hasConceptScore W2079667503C162317418 @default.
• W2079667503 hasConceptScore W2079667503C181152851 @default.
• W2079667503 hasConceptScore W2079667503C18431079 @default.
• W2079667503 hasConceptScore W2079667503C204232928 @default.
• W2079667503 hasConceptScore W2079667503C2779013556 @default.
• W2079667503 hasConceptScore W2079667503C2780352672 @default.
• W2079667503 hasConceptScore W2079667503C502942594 @default.

• next