FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079668385> ?p ?o ?g. }

• W2079668385 endingPage "120" @default.
• W2079668385 startingPage "105" @default.
• W2079668385 abstract "Despite recent major strides in our understanding of the genetic and microbial influences that contribute to the development of the inflammatory bowel diseases (IBDs), their etiology continues to be enigmatic. Results from experiments in animal models of IBDs overwhelmingly support a causal role of the microbiota in these diseases, though whether such a cause-effect relationship exists in human IBDs is still uncertain. Therefore, virtually all currently approved and most often prescribed treatments for IBDs are directed toward the over-active immune response in these diseases rather than the intestinal bacteria. Nevertheless, there is an important need for non-immunosuppressive therapies that may present a more favorable risk-benefit profile such as those that selectively target the disruptions in gut microbiota that accompany IBDs. This need has led to clinical trials of various microbial-directed therapies including fecal microbial transplant, antibiotics, probiotics, and prebiotics. Unfortunately, these published studies, many of which are small, have generally failed to demonstrate a consistent benefit of these agents in IBDs, thus leading to slow acceptance of microbe-focused treatments for these conditions. In this article, we review and summarize the microbial basis for IBDs and the results of the most recent trials of fecal microbial transplant, antibiotics, probiotics, and prebiotics in IBDs. We also comment on possible safety concerns with these agents, speculate on why they have failed to show efficacy in certain clinical settings, and propose strategies to improve their usefulness." @default.
• W2079668385 created "2016-06-24" @default.
• W2079668385 creator A5046780332 @default.
• W2079668385 creator A5049586381 @default.
• W2079668385 date "2015-01-18" @default.
• W2079668385 modified "2023-10-11" @default.
• W2079668385 title "Therapeutic Manipulation of the Microbiome in IBD: Current Results and Future Approaches" @default.
• W2079668385 cites W115652435 @default.
• W2079668385 cites W133234478 @default.
• W2079668385 cites W1495179622 @default.
• W2079668385 cites W1549833421 @default.
• W2079668385 cites W1646325020 @default.
• W2079668385 cites W1706367474 @default.
• W2079668385 cites W1785027726 @default.
• W2079668385 cites W1792471343 @default.
• W2079668385 cites W1866740209 @default.
• W2079668385 cites W1954857031 @default.
• W2079668385 cites W1966893199 @default.
• W2079668385 cites W1969879447 @default.
• W2079668385 cites W1975030443 @default.
• W2079668385 cites W1975092923 @default.
• W2079668385 cites W1975601232 @default.
• W2079668385 cites W1977475121 @default.
• W2079668385 cites W1978345442 @default.
• W2079668385 cites W1978922943 @default.
• W2079668385 cites W1980212383 @default.
• W2079668385 cites W1981266729 @default.
• W2079668385 cites W1983728610 @default.
• W2079668385 cites W1985107572 @default.
• W2079668385 cites W1990726902 @default.
• W2079668385 cites W1990966899 @default.
• W2079668385 cites W1993316662 @default.
• W2079668385 cites W1997405434 @default.
• W2079668385 cites W1997563854 @default.
• W2079668385 cites W1998335236 @default.
• W2079668385 cites W1998505107 @default.
• W2079668385 cites W1999906527 @default.
• W2079668385 cites W2001113033 @default.
• W2079668385 cites W2002477604 @default.
• W2079668385 cites W2003342633 @default.
• W2079668385 cites W2012030912 @default.
• W2079668385 cites W2018091449 @default.
• W2079668385 cites W2018568214 @default.
• W2079668385 cites W2024192805 @default.
• W2079668385 cites W2028301093 @default.
• W2079668385 cites W2028402416 @default.
• W2079668385 cites W2029310248 @default.
• W2079668385 cites W2030491651 @default.
• W2079668385 cites W2031443391 @default.
• W2079668385 cites W2033973171 @default.
• W2079668385 cites W2037111559 @default.
• W2079668385 cites W2040935889 @default.
• W2079668385 cites W2041136224 @default.
• W2079668385 cites W2041633812 @default.
• W2079668385 cites W2045440836 @default.
• W2079668385 cites W2048801983 @default.
• W2079668385 cites W2049779424 @default.
• W2079668385 cites W2063518063 @default.
• W2079668385 cites W2065975935 @default.
• W2079668385 cites W2072447308 @default.
• W2079668385 cites W2076658981 @default.
• W2079668385 cites W2076694193 @default.
• W2079668385 cites W2078745520 @default.
• W2079668385 cites W2083513339 @default.
• W2079668385 cites W2085284704 @default.
• W2079668385 cites W2091250795 @default.
• W2079668385 cites W2091300232 @default.
• W2079668385 cites W2094682242 @default.
• W2079668385 cites W2096008599 @default.
• W2079668385 cites W2098452439 @default.
• W2079668385 cites W2102286134 @default.
• W2079668385 cites W2103561589 @default.
• W2079668385 cites W2103966018 @default.
• W2079668385 cites W2115800864 @default.
• W2079668385 cites W2116570187 @default.
• W2079668385 cites W2118017902 @default.
• W2079668385 cites W2121245825 @default.
• W2079668385 cites W2124240205 @default.
• W2079668385 cites W2124334818 @default.
• W2079668385 cites W2128474861 @default.
• W2079668385 cites W2132135531 @default.
• W2079668385 cites W2135433890 @default.
• W2079668385 cites W2135618196 @default.
• W2079668385 cites W2136419595 @default.
• W2079668385 cites W2136552678 @default.
• W2079668385 cites W2138049155 @default.
• W2079668385 cites W2139387284 @default.
• W2079668385 cites W2139607262 @default.
• W2079668385 cites W2141125135 @default.
• W2079668385 cites W2142286221 @default.
• W2079668385 cites W2143625465 @default.
• W2079668385 cites W2143777796 @default.
• W2079668385 cites W2144275312 @default.
• W2079668385 cites W2146400193 @default.
• W2079668385 cites W2148171446 @default.
• W2079668385 cites W2148859286 @default.
• W2079668385 cites W2150366828 @default.
• W2079668385 cites W2152359084 @default.

• next