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• W2079671119 endingPage "466" @default.
• W2079671119 startingPage "466" @default.
• W2079671119 abstract "Evolution via point mutations is a relatively slow process and is unlikely to completely explain the differences between primates and other mammals. By contrast, 45% of the human genome is composed of retroposed elements, many of which were inserted in the primate lineage. A subset of retroposed mRNAs (retrocopies) shows strong evidence of expression in primates, often yielding functional retrogenes. To identify and analyze the relatively recently evolved retrogenes, we carried out BLASTZ alignments of all human mRNAs against the human genome and scored a set of features indicative of retroposition. Of over 12,000 putative retrocopy-derived genes that arose mainly in the primate lineage, 726 with strong evidence of transcript expression were examined in detail. These mRNA retroposition events fall into three categories: I) 34 retrocopies and antisense retrocopies that added potential protein coding space and UTRs to existing genes; II) 682 complete retrocopy duplications inserted into new loci; and III) an unexpected set of 13 retrocopies that contributed out-of-frame, or antisense sequences in combination with other types of transposed elements (SINEs, LINEs, LTRs), even unannotated sequence to form potentially novel genes with no homologs outside primates. In addition to their presence in human, several of the gene candidates also had potentially viable ORFs in chimpanzee, orangutan, and rhesus macaque, underscoring their potential of function. mRNA-derived retrocopies provide raw material for the evolution of genes in a wide variety of ways, duplicating and amending the protein coding region of existing genes as well as generating the potential for new protein coding space, or non-protein coding RNAs, by unexpected contributions out of frame, in reverse orientation, or from previously non-protein coding sequence." @default.
• W2079671119 created "2016-06-24" @default.
• W2079671119 creator A5006195366 @default.
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• W2079671119 creator A5090849321 @default.
• W2079671119 date "2008-01-01" @default.
• W2079671119 modified "2023-10-10" @default.
• W2079671119 title "Retrocopy contributions to the evolution of the human genome" @default.
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• W2079671119 doi "https://doi.org/10.1186/1471-2164-9-466" @default.
• W2079671119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2584115" @default.
• W2079671119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18842134" @default.
• W2079671119 hasPublicationYear "2008" @default.
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