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• W2079671310 startingPage "301" @default.
• W2079671310 abstract "Activation of dendritic voltage-gated ion channels by local synaptic input was tested by simultaneous dendrite-attached patch-clamp recordings and whole-cell somatic voltage recordings made from CA1 pyramidal neurons in hippocampal slices. Schaffer collateral stimulation elicited subthreshold excitatory postsynaptic potentials (EPSPs) that opened voltage-gated sodium and calcium channels in the apical dendrites. The EPSP-activated sodium channels opened near the peak of the EPSP, whereas low voltage-activated calcium channels opened near the EPSP peak and during the decay phase. Dendritic high voltage-activated channels required somatic action potential generation or suprathreshold synaptic trains for activation. Dendritic voltage-gated channels are, therefore, likely to participate in dendritic integration of synaptic events." @default.
• W2079671310 created "2016-06-24" @default.
• W2079671310 creator A5010467709 @default.
• W2079671310 creator A5043288520 @default.
• W2079671310 date "1995-04-14" @default.
• W2079671310 modified "2023-09-25" @default.
• W2079671310 title "Synaptic Activation of Voltage-Gated Channels in the Dendrites of Hippocampal Pyramidal Neurons" @default.
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• W2079671310 doi "https://doi.org/10.1126/science.7716525" @default.
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