Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079672382> ?p ?o ?g. }
- W2079672382 endingPage "197" @default.
- W2079672382 startingPage "183" @default.
- W2079672382 abstract "The delayed outward rectifier K+ channel has a role in the increase in automaticity of myocytes under pathophysiological conditions. The purpose of the present study was to clarify the effect of blockade of outward recitifier K+ channels by a class III antiarrhythmic drug, E4031, on ischemia- and reperfusion-induced arrhythmias. Ion fluxes, energy metabolites and cardiac function were measured and the epicardial electrocardiograms of Langendorffperfused rat hearts were recorded during initial perfusion, global or regional ischemia and reperfusion. 10-7M of E4031 administered during the initial perfusion did not prolong the QT interval, but slowed the heart rate (Control: 222, E4031: 183bpm, p<0.05), increased myocardial 45Ca2+ uptake (Control: 2.1, E4031: 2.9μmol/g dwt, p<0.05) and attenuated the loss of intracellular K+ during ischemia (Control: 238, E4031: 248μmol/g dwt, p<0.05). E4031 tended to reduce ischemia-induced ventricular tachyarrhythmias (Control: 60, E4031: 30%, n. s.), but reperfusion-induced ventricular tachyarrhythmias were sustained longer by the administration of E4031 (Control: 255, E4031: 623sec, p<0.05). Prior exposure to E4031 decreased the depletion of high energy phosphates during ischemia, but suppressed their recovery during reperfusion. These results suggest that the attenuated loss of K+ from the ischemic myocardium and the decrease in heart rate by E4031 contributed to the reduction of ischemia-induced arrhythmias. However, the increase in myocardial Ca2+ uptake and altered energy metabolism may be responsible for the increase in reperfusion-induced arrhythmias.(Jpn HeartJ 1998; 39: 183-197)" @default.
- W2079672382 created "2016-06-24" @default.
- W2079672382 creator A5018746363 @default.
- W2079672382 creator A5047822588 @default.
- W2079672382 creator A5063696540 @default.
- W2079672382 creator A5064893718 @default.
- W2079672382 creator A5067806725 @default.
- W2079672382 date "1998-01-01" @default.
- W2079672382 modified "2023-09-23" @default.
- W2079672382 title "Effect of E4031, a Class III Antiarrhythmic Drug, on Ischemia- and Reperfusion-induced Arrhythmias in Isolated Rat Hearts." @default.
- W2079672382 cites W1566830427 @default.
- W2079672382 cites W1973132554 @default.
- W2079672382 cites W1975869151 @default.
- W2079672382 cites W1987676379 @default.
- W2079672382 cites W1988577370 @default.
- W2079672382 cites W1989715394 @default.
- W2079672382 cites W1996841345 @default.
- W2079672382 cites W1997768837 @default.
- W2079672382 cites W2002374666 @default.
- W2079672382 cites W2007448071 @default.
- W2079672382 cites W2008511303 @default.
- W2079672382 cites W2008833408 @default.
- W2079672382 cites W2014140660 @default.
- W2079672382 cites W2014487862 @default.
- W2079672382 cites W2014775135 @default.
- W2079672382 cites W2019549459 @default.
- W2079672382 cites W2022627207 @default.
- W2079672382 cites W2029099957 @default.
- W2079672382 cites W2030112920 @default.
- W2079672382 cites W2046989975 @default.
- W2079672382 cites W2047563687 @default.
- W2079672382 cites W2057740129 @default.
- W2079672382 cites W2057994986 @default.
- W2079672382 cites W2064953660 @default.
- W2079672382 cites W2066789391 @default.
- W2079672382 cites W2067152768 @default.
- W2079672382 cites W2067552289 @default.
- W2079672382 cites W2074489127 @default.
- W2079672382 cites W2074974258 @default.
- W2079672382 cites W2075021708 @default.
- W2079672382 cites W2083687879 @default.
- W2079672382 cites W2084132331 @default.
- W2079672382 cites W2089950442 @default.
- W2079672382 cites W2090546740 @default.
- W2079672382 cites W2094992107 @default.
- W2079672382 cites W2113100859 @default.
- W2079672382 cites W2115936524 @default.
- W2079672382 cites W2120173321 @default.
- W2079672382 cites W2133488495 @default.
- W2079672382 cites W2149807266 @default.
- W2079672382 cites W2153475498 @default.
- W2079672382 cites W2169355421 @default.
- W2079672382 cites W2233212932 @default.
- W2079672382 cites W2282057122 @default.
- W2079672382 cites W2287532635 @default.
- W2079672382 cites W2320753159 @default.
- W2079672382 cites W2408793589 @default.
- W2079672382 cites W2409207570 @default.
- W2079672382 doi "https://doi.org/10.1536/ihj.39.183" @default.
- W2079672382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9687827" @default.
- W2079672382 hasPublicationYear "1998" @default.
- W2079672382 type Work @default.
- W2079672382 sameAs 2079672382 @default.
- W2079672382 citedByCount "13" @default.
- W2079672382 countsByYear W20796723822012 @default.
- W2079672382 countsByYear W20796723822015 @default.
- W2079672382 crossrefType "journal-article" @default.
- W2079672382 hasAuthorship W2079672382A5018746363 @default.
- W2079672382 hasAuthorship W2079672382A5047822588 @default.
- W2079672382 hasAuthorship W2079672382A5063696540 @default.
- W2079672382 hasAuthorship W2079672382A5064893718 @default.
- W2079672382 hasAuthorship W2079672382A5067806725 @default.
- W2079672382 hasBestOaLocation W20796723821 @default.
- W2079672382 hasConcept C126322002 @default.
- W2079672382 hasConcept C146957229 @default.
- W2079672382 hasConcept C164705383 @default.
- W2079672382 hasConcept C2778131192 @default.
- W2079672382 hasConcept C2779161974 @default.
- W2079672382 hasConcept C2780074459 @default.
- W2079672382 hasConcept C2910096629 @default.
- W2079672382 hasConcept C541997718 @default.
- W2079672382 hasConcept C71924100 @default.
- W2079672382 hasConcept C98274493 @default.
- W2079672382 hasConceptScore W2079672382C126322002 @default.
- W2079672382 hasConceptScore W2079672382C146957229 @default.
- W2079672382 hasConceptScore W2079672382C164705383 @default.
- W2079672382 hasConceptScore W2079672382C2778131192 @default.
- W2079672382 hasConceptScore W2079672382C2779161974 @default.
- W2079672382 hasConceptScore W2079672382C2780074459 @default.
- W2079672382 hasConceptScore W2079672382C2910096629 @default.
- W2079672382 hasConceptScore W2079672382C541997718 @default.
- W2079672382 hasConceptScore W2079672382C71924100 @default.
- W2079672382 hasConceptScore W2079672382C98274493 @default.
- W2079672382 hasIssue "2" @default.
- W2079672382 hasLocation W20796723821 @default.
- W2079672382 hasLocation W20796723822 @default.
- W2079672382 hasOpenAccess W2079672382 @default.
- W2079672382 hasPrimaryLocation W20796723821 @default.