Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079672471> ?p ?o ?g. }
- W2079672471 endingPage "116" @default.
- W2079672471 startingPage "109" @default.
- W2079672471 abstract "A major objective in vaccine development is the design of reagents that give a strong, specific T cell response. Targeting of antigens to antigen presenting cells (APC) results in enhanced antigen presentation and T cell activation. In this paper, we describe a novel targeting reagent denoted 'Troy-bodies', namely recombinant antibodies with APC-specificity and with T cell epitopes integrated in their C regions. We have made such antibodies with V regions specific for either IgD or MHC class II, and five different T cell epitopes have been tested. All epitopes could be introduced into loops of C domains without disrupting immunoglobulin (Ig) folding. Four have been tested in T cell activation studies, and all could be released and presented by APC. Furthermore, whether IgD- or MHC-specific, the molecules tested enhanced T cell stimulation compared to non-specific control antibodies in vitro as well as in vivo. Using this technology, specific reagents can be designed that target selected antigenic peptides to an APC of choice. Troy-bodies may therefore be useful for manipulation of immune responses, and in particular for vaccination purposes." @default.
- W2079672471 created "2016-06-24" @default.
- W2079672471 creator A5045878198 @default.
- W2079672471 creator A5048845155 @default.
- W2079672471 creator A5049377131 @default.
- W2079672471 creator A5055661854 @default.
- W2079672471 creator A5067642041 @default.
- W2079672471 creator A5070710923 @default.
- W2079672471 creator A5083802834 @default.
- W2079672471 date "2001-10-01" @default.
- W2079672471 modified "2023-09-24" @default.
- W2079672471 title "‘Troy-bodies’: antibodies as vector proteins for T cell epitopes" @default.
- W2079672471 cites W1480473417 @default.
- W2079672471 cites W1493865972 @default.
- W2079672471 cites W1509030499 @default.
- W2079672471 cites W1510178428 @default.
- W2079672471 cites W1523616589 @default.
- W2079672471 cites W1551760143 @default.
- W2079672471 cites W1567891725 @default.
- W2079672471 cites W1768650192 @default.
- W2079672471 cites W1829865624 @default.
- W2079672471 cites W1939480513 @default.
- W2079672471 cites W1968665624 @default.
- W2079672471 cites W1975867261 @default.
- W2079672471 cites W1976981613 @default.
- W2079672471 cites W1989231165 @default.
- W2079672471 cites W1998109852 @default.
- W2079672471 cites W2000251753 @default.
- W2079672471 cites W2002073873 @default.
- W2079672471 cites W2004443127 @default.
- W2079672471 cites W2006106040 @default.
- W2079672471 cites W2011995348 @default.
- W2079672471 cites W2012219819 @default.
- W2079672471 cites W2014957283 @default.
- W2079672471 cites W2016868551 @default.
- W2079672471 cites W2018317049 @default.
- W2079672471 cites W2018680787 @default.
- W2079672471 cites W2021816348 @default.
- W2079672471 cites W2027178598 @default.
- W2079672471 cites W2028350378 @default.
- W2079672471 cites W2035960239 @default.
- W2079672471 cites W2036277985 @default.
- W2079672471 cites W2043304777 @default.
- W2079672471 cites W2046410511 @default.
- W2079672471 cites W2049389722 @default.
- W2079672471 cites W2058071227 @default.
- W2079672471 cites W2058175157 @default.
- W2079672471 cites W2069414653 @default.
- W2079672471 cites W2076209651 @default.
- W2079672471 cites W2084743858 @default.
- W2079672471 cites W2085831528 @default.
- W2079672471 cites W2087545042 @default.
- W2079672471 cites W2090449825 @default.
- W2079672471 cites W2096946570 @default.
- W2079672471 cites W2099893709 @default.
- W2079672471 cites W2100509873 @default.
- W2079672471 cites W2130867278 @default.
- W2079672471 cites W2150760619 @default.
- W2079672471 cites W2153925787 @default.
- W2079672471 cites W2155688181 @default.
- W2079672471 cites W2157158745 @default.
- W2079672471 cites W2163021423 @default.
- W2079672471 cites W2170294980 @default.
- W2079672471 cites W2170707246 @default.
- W2079672471 cites W2170760065 @default.
- W2079672471 cites W2235734178 @default.
- W2079672471 cites W290550136 @default.
- W2079672471 cites W4231136244 @default.
- W2079672471 doi "https://doi.org/10.1016/s1389-0344(01)00091-0" @default.
- W2079672471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11566602" @default.
- W2079672471 hasPublicationYear "2001" @default.
- W2079672471 type Work @default.
- W2079672471 sameAs 2079672471 @default.
- W2079672471 citedByCount "7" @default.
- W2079672471 countsByYear W20796724712014 @default.
- W2079672471 countsByYear W20796724712016 @default.
- W2079672471 countsByYear W20796724712017 @default.
- W2079672471 crossrefType "journal-article" @default.
- W2079672471 hasAuthorship W2079672471A5045878198 @default.
- W2079672471 hasAuthorship W2079672471A5048845155 @default.
- W2079672471 hasAuthorship W2079672471A5049377131 @default.
- W2079672471 hasAuthorship W2079672471A5055661854 @default.
- W2079672471 hasAuthorship W2079672471A5067642041 @default.
- W2079672471 hasAuthorship W2079672471A5070710923 @default.
- W2079672471 hasAuthorship W2079672471A5083802834 @default.
- W2079672471 hasConcept C147483822 @default.
- W2079672471 hasConcept C153911025 @default.
- W2079672471 hasConcept C159654299 @default.
- W2079672471 hasConcept C195616568 @default.
- W2079672471 hasConcept C203014093 @default.
- W2079672471 hasConcept C207936829 @default.
- W2079672471 hasConcept C2776090121 @default.
- W2079672471 hasConcept C2778453870 @default.
- W2079672471 hasConcept C48010095 @default.
- W2079672471 hasConcept C67662055 @default.
- W2079672471 hasConcept C83464605 @default.
- W2079672471 hasConcept C86803240 @default.
- W2079672471 hasConcept C8891405 @default.