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- W2079673406 abstract "To study basal and ACTH stimulated levels of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), and cortisol (F) in healthy girls during prepuberty.Six prepubertal girls, ages 3.7-10.9 years.The six girls underwent a physical examination and an acute ACTH stimulation test on a yearly basis. Serum DHEA, DHEAS, A4, and F at 0 min (Steroid0) and 60 min (Steroid60) after 0.25 mg ACTH1-24 i.v., and the net increment (delta Steroid60-0) were calculated.DHEAS0, DHEAS60, DHEA0, DHEA60 and A40 were positively correlated to chronological age. DHEAS0 and DHEAS60 levels rose gradually beginning at 6.1-7.0 years of chronological age, and were found to be significantly different at 9.1-10.0 years and 10.1-11.0 years of age, compared to the median values obtained at < or =6.0 years of age. There was a tendency for DHEA0, DHEA60, and A40 to increase beginning at 9.1-10.0 years of age. Net increment values of all hormones did not change throughout the study.An increase in the circulating level of DHEAS appears to be the first event observed during adrenarche, prior to clinical evidence of the process." @default.
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- W2079673406 date "2004-01-01" @default.
- W2079673406 modified "2023-09-27" @default.
- W2079673406 title "Early Adrenarche in Normal Prepubertal Girls: A Prospective Longitudinal Study" @default.
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- W2079673406 doi "https://doi.org/10.1515/jpem.2004.17.9.1231" @default.
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