FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079675650> ?p ?o ?g. }

• W2079675650 endingPage "E60" @default.
• W2079675650 startingPage "E54" @default.
• W2079675650 abstract "The purpose of this study was to achieve a better therapeutic efficacy and patient compliance in the treatment for vaginitis. Clotrimazole (1%) has been formulated in a vaginal gel using the thermosensitive polymer Pluronic F127 (20%) together with mucoadhesive polymers such as Carbopol 934 and hydroxypropylmethylcellulose (0.2% for both). To increase its aqueous solubility., clotrimazole was incorporated as its inclusion complex with 1∶1 molar ratio with β-cyclodextrin. The inclusion complex was thoroughly characterized using various techniques, including 1H NMR spectroscopy, FT IR spectrophotometry, differential scanning calorimetry, scanning electron microscopy, phase solubility studies, and determination of stability constant (k1∶1). The gelation temperature and rheological behavior of different formulations at varying temperatures were measured. In vitro release profiles of the gels were determined in pH 5.5 citrate buffer. It was observed that complexation with cyclodextrin slowed down the release of clotrimazole considerably. Carbopol 934, on the other hand, was found to interact with β-cyclodextrin, inducing precipitation. As far as rheological properties are concerned, thermosensitive in situ gelling was obtained with formulations containing drug: cyclodextrin complex rather than with free drug. Thus, the optimum formulation for a controlled-release thermosensitive and mucoadhesive vaginal gel was determined to be clotrimazole: β-cyclodextrin 1% with 0.2% hydroxypropylmethylcellulose in Pluronic F127 gel (20%) providing continuous and prolonged release of active material above MIC values." @default.
• W2079675650 created "2016-06-24" @default.
• W2079675650 creator A5017864076 @default.
• W2079675650 creator A5032281318 @default.
• W2079675650 creator A5043086289 @default.
• W2079675650 creator A5058434867 @default.
• W2079675650 creator A5076504878 @default.
• W2079675650 date "2006-06-01" @default.
• W2079675650 modified "2023-10-15" @default.
• W2079675650 title "Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole: β-cyclodextrin complex" @default.
• W2079675650 cites W1558966030 @default.
• W2079675650 cites W1566583318 @default.
• W2079675650 cites W1600228194 @default.
• W2079675650 cites W1963893922 @default.
• W2079675650 cites W1964233750 @default.
• W2079675650 cites W1965650360 @default.
• W2079675650 cites W1968902554 @default.
• W2079675650 cites W1973579525 @default.
• W2079675650 cites W1975771377 @default.
• W2079675650 cites W1976236482 @default.
• W2079675650 cites W1977615064 @default.
• W2079675650 cites W1987723349 @default.
• W2079675650 cites W1994713846 @default.
• W2079675650 cites W2003310438 @default.
• W2079675650 cites W2003936338 @default.
• W2079675650 cites W2010303814 @default.
• W2079675650 cites W2020965737 @default.
• W2079675650 cites W2021922734 @default.
• W2079675650 cites W2023772978 @default.
• W2079675650 cites W2024987886 @default.
• W2079675650 cites W2030295309 @default.
• W2079675650 cites W2033632772 @default.
• W2079675650 cites W2038265772 @default.
• W2079675650 cites W2046017608 @default.
• W2079675650 cites W2047034140 @default.
• W2079675650 cites W2054016731 @default.
• W2079675650 cites W2069139795 @default.
• W2079675650 cites W2073394985 @default.
• W2079675650 cites W2074087796 @default.
• W2079675650 cites W2075545024 @default.
• W2079675650 cites W2089773698 @default.
• W2079675650 cites W2093348832 @default.
• W2079675650 cites W2100003552 @default.
• W2079675650 cites W2109133910 @default.
• W2079675650 cites W2116014851 @default.
• W2079675650 cites W2136476275 @default.
• W2079675650 cites W2137492526 @default.
• W2079675650 cites W2140127287 @default.
• W2079675650 cites W2154014672 @default.
• W2079675650 cites W2159140870 @default.
• W2079675650 cites W4230878297 @default.
• W2079675650 cites W4236270159 @default.
• W2079675650 doi "https://doi.org/10.1208/pt070238" @default.
• W2079675650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2750288" @default.
• W2079675650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16796356" @default.
• W2079675650 hasPublicationYear "2006" @default.
• W2079675650 type Work @default.
• W2079675650 sameAs 2079675650 @default.
• W2079675650 citedByCount "126" @default.
• W2079675650 countsByYear W20796756502012 @default.
• W2079675650 countsByYear W20796756502013 @default.
• W2079675650 countsByYear W20796756502014 @default.
• W2079675650 countsByYear W20796756502015 @default.
• W2079675650 countsByYear W20796756502016 @default.
• W2079675650 countsByYear W20796756502017 @default.
• W2079675650 countsByYear W20796756502018 @default.
• W2079675650 countsByYear W20796756502019 @default.
• W2079675650 countsByYear W20796756502020 @default.
• W2079675650 countsByYear W20796756502021 @default.
• W2079675650 countsByYear W20796756502022 @default.
• W2079675650 countsByYear W20796756502023 @default.
• W2079675650 crossrefType "journal-article" @default.
• W2079675650 hasAuthorship W2079675650A5017864076 @default.
• W2079675650 hasAuthorship W2079675650A5032281318 @default.
• W2079675650 hasAuthorship W2079675650A5043086289 @default.
• W2079675650 hasAuthorship W2079675650A5058434867 @default.
• W2079675650 hasAuthorship W2079675650A5076504878 @default.
• W2079675650 hasBestOaLocation W20796756502 @default.
• W2079675650 hasConcept C101335993 @default.
• W2079675650 hasConcept C121332964 @default.
• W2079675650 hasConcept C13965031 @default.
• W2079675650 hasConcept C155574463 @default.
• W2079675650 hasConcept C15920480 @default.
• W2079675650 hasConcept C16005928 @default.
• W2079675650 hasConcept C178790620 @default.
• W2079675650 hasConcept C185592680 @default.
• W2079675650 hasConcept C2777239854 @default.
• W2079675650 hasConcept C2779433975 @default.
• W2079675650 hasConcept C2779548794 @default.
• W2079675650 hasConcept C2780628323 @default.
• W2079675650 hasConcept C39519442 @default.
• W2079675650 hasConcept C43617362 @default.
• W2079675650 hasConcept C521977710 @default.
• W2079675650 hasConcept C71924100 @default.
• W2079675650 hasConcept C97355855 @default.
• W2079675650 hasConceptScore W2079675650C101335993 @default.
• W2079675650 hasConceptScore W2079675650C121332964 @default.
• W2079675650 hasConceptScore W2079675650C13965031 @default.

• next