FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079676235> ?p ?o ?g. }

• W2079676235 endingPage "204" @default.
• W2079676235 startingPage "199" @default.
• W2079676235 abstract "Cytotoxic T lymphocyte antigen 4 (CTLA4) appears to negatively regulate T cell activation. One mechanism by which CTLA4 might antagonize T cell function is through inhibition of CD28 signaling by competing for their shared ligands B7-1 and B7-2. In addition, CTLA4 ligation could initiate a signaling cascade that inhibits T cell activation. To address whether CTLA4 could inhibit immune responses in the absence of CD28, rejection of heart allografts was studied in CD28-deficient mice. H-2q hearts were transplanted into allogeneic wild-type or CD28-deficient mice (H-2b). Graft rejection was delayed in CD28-deficient compared with wild-type mice. Treatment of wild-type recipients with CTLA4-immunoglobulin (Ig), or with anti–B7-1 plus anti–B7-2 mAbs significantly prolonged allograft survival. In contrast, treatment of CD28-deficient mice with CTLA4-Ig, anti–B7-1 plus anti–B7-2 mAbs, or a blocking anti-CTLA4 mAb induced acceleration of allograft rejection. This increased rate of graft rejection was associated with more severe mononuclear cell infiltration and enhanced levels of IFN-γ and IL-6 transcripts in donor hearts of untreated wild-type and CTLA4-Ig– or anti-CTLA4 mAb–treated CD28-deficient mice. Thus, the negative regulatory role of CTLA4 extends beyond its potential ability to prevent CD28 activation through ligand competition. Even in the absence of CD28, CTLA4 plays an inhibitory role in the regulation of allograft rejection." @default.
• W2079676235 created "2016-06-24" @default.
• W2079676235 creator A5021007344 @default.
• W2079676235 creator A5023053917 @default.
• W2079676235 creator A5039225909 @default.
• W2079676235 creator A5049185871 @default.
• W2079676235 creator A5053752263 @default.
• W2079676235 creator A5056373193 @default.
• W2079676235 date "1998-07-01" @default.
• W2079676235 modified "2023-10-16" @default.
• W2079676235 title "Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28" @default.
• W2079676235 cites W1628976024 @default.
• W2079676235 cites W1964591258 @default.
• W2079676235 cites W1968546256 @default.
• W2079676235 cites W2001868699 @default.
• W2079676235 cites W2015085911 @default.
• W2079676235 cites W2017331094 @default.
• W2079676235 cites W2017760087 @default.
• W2079676235 cites W2043007190 @default.
• W2079676235 cites W2048073154 @default.
• W2079676235 cites W2048198121 @default.
• W2079676235 cites W2076067786 @default.
• W2079676235 cites W2076169910 @default.
• W2079676235 cites W2090481553 @default.
• W2079676235 cites W2094366129 @default.
• W2079676235 cites W2104036678 @default.
• W2079676235 cites W2114256900 @default.
• W2079676235 cites W2123761806 @default.
• W2079676235 cites W2140066663 @default.
• W2079676235 cites W2146907765 @default.
• W2079676235 cites W2161367133 @default.
• W2079676235 cites W2162466652 @default.
• W2079676235 cites W2164903177 @default.
• W2079676235 cites W2409154769 @default.
• W2079676235 doi "https://doi.org/10.1084/jem.188.1.199" @default.
• W2079676235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2525553" @default.
• W2079676235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9653096" @default.
• W2079676235 hasPublicationYear "1998" @default.
• W2079676235 type Work @default.
• W2079676235 sameAs 2079676235 @default.
• W2079676235 citedByCount "180" @default.
• W2079676235 countsByYear W20796762352012 @default.
• W2079676235 countsByYear W20796762352013 @default.
• W2079676235 countsByYear W20796762352014 @default.
• W2079676235 countsByYear W20796762352015 @default.
• W2079676235 countsByYear W20796762352016 @default.
• W2079676235 countsByYear W20796762352017 @default.
• W2079676235 countsByYear W20796762352018 @default.
• W2079676235 countsByYear W20796762352019 @default.
• W2079676235 countsByYear W20796762352020 @default.
• W2079676235 countsByYear W20796762352021 @default.
• W2079676235 countsByYear W20796762352023 @default.
• W2079676235 crossrefType "journal-article" @default.
• W2079676235 hasAuthorship W2079676235A5021007344 @default.
• W2079676235 hasAuthorship W2079676235A5023053917 @default.
• W2079676235 hasAuthorship W2079676235A5039225909 @default.
• W2079676235 hasAuthorship W2079676235A5049185871 @default.
• W2079676235 hasAuthorship W2079676235A5053752263 @default.
• W2079676235 hasAuthorship W2079676235A5056373193 @default.
• W2079676235 hasBestOaLocation W20796762351 @default.
• W2079676235 hasConcept C147483822 @default.
• W2079676235 hasConcept C148125776 @default.
• W2079676235 hasConcept C154317977 @default.
• W2079676235 hasConcept C202751555 @default.
• W2079676235 hasConcept C203014093 @default.
• W2079676235 hasConcept C2776090121 @default.
• W2079676235 hasConcept C2992881475 @default.
• W2079676235 hasConcept C502942594 @default.
• W2079676235 hasConcept C55493867 @default.
• W2079676235 hasConcept C86803240 @default.
• W2079676235 hasConcept C8891405 @default.
• W2079676235 hasConceptScore W2079676235C147483822 @default.
• W2079676235 hasConceptScore W2079676235C148125776 @default.
• W2079676235 hasConceptScore W2079676235C154317977 @default.
• W2079676235 hasConceptScore W2079676235C202751555 @default.
• W2079676235 hasConceptScore W2079676235C203014093 @default.
• W2079676235 hasConceptScore W2079676235C2776090121 @default.
• W2079676235 hasConceptScore W2079676235C2992881475 @default.
• W2079676235 hasConceptScore W2079676235C502942594 @default.
• W2079676235 hasConceptScore W2079676235C55493867 @default.
• W2079676235 hasConceptScore W2079676235C86803240 @default.
• W2079676235 hasConceptScore W2079676235C8891405 @default.
• W2079676235 hasIssue "1" @default.
• W2079676235 hasLocation W20796762351 @default.
• W2079676235 hasLocation W20796762352 @default.
• W2079676235 hasLocation W20796762353 @default.
• W2079676235 hasLocation W20796762354 @default.
• W2079676235 hasOpenAccess W2079676235 @default.
• W2079676235 hasPrimaryLocation W20796762351 @default.
• W2079676235 hasRelatedWork W1969897672 @default.
• W2079676235 hasRelatedWork W2008949385 @default.
• W2079676235 hasRelatedWork W2056385328 @default.
• W2079676235 hasRelatedWork W2060451389 @default.
• W2079676235 hasRelatedWork W2062443745 @default.
• W2079676235 hasRelatedWork W2166647373 @default.
• W2079676235 hasRelatedWork W2220102944 @default.
• W2079676235 hasRelatedWork W2313905710 @default.
• W2079676235 hasRelatedWork W2409441623 @default.

• next