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- W2079676799 abstract "Though less potent than the parent natural product leinamycin, S-deoxyleinamycin displays activity against human cancer cell lines that is comparable to many clinically used agents. The results reported here suggest that the 1,2-dithiolan-3-one heterocycle found in S-deoxyleinamycin reacts with thiols to generate a persulfide intermediate (RSS−) that could deliver biologically active polysulfides, hydrogen sulfide, and reactive oxygen species (O2-, H2O2, and HO) to the interior of cells." @default.
- W2079676799 created "2016-06-24" @default.
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- W2079676799 date "2008-05-01" @default.
- W2079676799 modified "2023-09-25" @default.
- W2079676799 title "Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin" @default.
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- W2079676799 doi "https://doi.org/10.1016/j.bmcl.2007.11.092" @default.
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