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- W2079677207 abstract "The purpose of this study was to evaluate both the intraocular pressure (IOP)‐decreasing and neuroprotective effects of Rescula (0.12% unoprostone isopropyl) as an alternative therapy to beta‐ blockers with a long‐term drift effect in patients with glaucoma. Twenty‐eight patients with unilateral or bilateral glaucoma were treated with Rescula instead of the original beta‐blocker therapy. IOP was measured using a Goldmann applanation tonometer, and visual field defects were evaluated quantitatively by Humphrey automatic perimetry central 30‐2 threshold test. The mean follow‐up time was at least 1 year. Rescula achieved a significant ( p = 0.00001) and long‐lasting reduction in IOP (from 20.78 ± 2.71 to 17.14 ± 2.70 mmHg) in patients with open‐angle glaucoma after 12 months of follow‐up. It also demonstrated a significant ( p = 0.02) IOP‐reducing effect (from 20.67 ± 3.60 to 16.36 ± 3.67 mmHg) in patients with angle‐ closure glaucoma 12 months later. The mean deviation of visual field defects changed from −13.27 dB baseline to −10.64 dB at 12 months as evaluated by Humphrey field analyzer II central 30‐2 threshold test after Rescula; however, there was no statistical difference ( p = 0.098). Our results showed that Rescula has a significant IOP‐reducing effect as an alternative therapy to beta‐blockers with long‐term drift effect in patients with open‐angle and angle‐closure glaucoma. However, a neuroprotective effect to prevent further progression of the visual field defect in patients with glaucoma was not demonstrated in this study." @default.
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- W2079677207 date "2006-06-01" @default.
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- W2079677207 title "Rescula as an Alternative Therapy for Beta-Blockers with Long-Term Drift Effect in Glaucoma Patients" @default.
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- W2079677207 doi "https://doi.org/10.1016/s1607-551x(09)70310-9" @default.
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