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- W2079677941 endingPage "S75" @default.
- W2079677941 startingPage "S69" @default.
- W2079677941 abstract "Tissue factor (TF), the trigger of blood coagulation, is a 47 kDa membrane protein that also impacts on non-hemostatic processes, such as atherosclerosis, primary tumor growth and metastasis. TF binding to its ligand FVIIa induces activation of protease-activated receptor-2 and this event is thought to considerably influence atherosclerosis and tumor angiogenesis. TF-dependent activation of the coagulation cascade, rather than PAR-2 activation, then leads to the potentiation of metastasis. Importantly, a soluble alternatively spliced isoform of TF (asTF) has been discovered, but the function of asTF in hemostatic and non-hemostatic events is poorly understood. In this review, we aim to present a side-by-side evaluation of normally-spliced, full length TF (flTF) and asTF with regard to coagulant function, atherosclerosis, tumor progression and malignancy-associated thrombosis." @default.
- W2079677941 created "2016-06-24" @default.
- W2079677941 creator A5002855882 @default.
- W2079677941 creator A5074449195 @default.
- W2079677941 date "2012-04-01" @default.
- W2079677941 modified "2023-10-18" @default.
- W2079677941 title "Tissue factor isoforms in cancer and coagulation: May the best isoform win" @default.
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- W2079677941 doi "https://doi.org/10.1016/s0049-3848(12)70020-8" @default.
- W2079677941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22682138" @default.
- W2079677941 hasPublicationYear "2012" @default.
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