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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079678586> ?p ?o ?g. }

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• W2079678586 abstract "During the past decade, the emerging effect of targeted therapies has led to a therapeutic paradigm shift in lung cancer. A driver gene alteration has been detected in 64% of lung adenocarcinoma cases. The epidermal growth factor receptor (EGFR) and echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) are important driver genes that have been found in 17% and 8% of patients, respectively.1 Previous studies have shown that an EGFR mutation and EML4-ALK fusion are mutually exclusive and that the coexistence of these 2 genes is associated with resistance to both EGFR tyrosine kinase inhibitors (TKIs) and ALK inhibitors." @default.
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• W2079678586 date "2015-03-01" @default.
• W2079678586 modified "2023-09-28" @default.
• W2079678586 title "Lung Adenocarcinoma Harboring Concomitant EGFR Mutation and EML4-ALK Fusion That Benefits From Three Kinds of Tyrosine Kinase Inhibitors: A Case Report and Literature Review" @default.
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• W2079678586 doi "https://doi.org/10.1016/j.cllc.2014.11.001" @default.
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