FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079678670> ?p ?o ?g. }

• W2079678670 endingPage "843" @default.
• W2079678670 startingPage "834" @default.
• W2079678670 abstract "Genetically modified mice with deficiency of the G protein α-subunit (G(s)α) in skeletal muscle showed metabolic abnormality with reduced glucose tolerance, low muscle mass, and low contractile force, along with a fast-to-slow-fiber-type switch (Chen M, Feng HZ, Gupta D, Kelleher J, Dickerson KE, Wang J, Hunt D, Jou W, Gavrilova O, Jin JP, Weinstein LS. Am J Physiol Cell Physiol 296: C930-C940, 2009). Here we investigated a hypothesis that the switching to more slow fibers is an adaptive response with specific benefit. The results showed that, corresponding to the switch of myosin isoforms, the thin-filament regulatory proteins troponin T and troponin I both switched to their slow isoforms in the atrophic soleus muscle of 3-mo-old G(s)α-deficient mice. This fiber-type switch involving coordinated changes of both thick- and thin-myofilament proteins progressed in the G(s)α-deficient soleus muscles of 18- to 24-mo-old mice, as reflected by the expression of solely slow isoforms of myosin and troponin. Compared with age-matched controls, G(s)α-deficient soleus muscles with higher proportion of slow fibers exhibited slower contractile and relaxation kinetics and lower developed force, but significantly increased resistance to fatigue, followed by a better recovery. G(s)α-deficient soleus muscles of neonatal and 3-wk-old mice did not show the increase in slow fibers. Therefore, the fast-to-slow-fiber-type switch in G(s)α deficiency at older ages was likely an adaptive response. The benefit of higher fatigue resistance in adaption to metabolic deficiency and aging provides a mechanism to sustain skeletal muscle function in diabetic patients and elderly individuals." @default.
• W2079678670 created "2016-06-24" @default.
• W2079678670 creator A5003919068 @default.
• W2079678670 creator A5012718640 @default.
• W2079678670 creator A5026699951 @default.
• W2079678670 creator A5035485086 @default.
• W2079678670 date "2011-09-01" @default.
• W2079678670 modified "2023-10-13" @default.
• W2079678670 title "Improved fatigue resistance in G_sα-deficient and aging mouse skeletal muscles due to adaptive increases in slow fibers" @default.
• W2079678670 cites W1580646470 @default.
• W2079678670 cites W1584195075 @default.
• W2079678670 cites W1770040190 @default.
• W2079678670 cites W1887455807 @default.
• W2079678670 cites W1898989394 @default.
• W2079678670 cites W1965621923 @default.
• W2079678670 cites W1969471587 @default.
• W2079678670 cites W1972718838 @default.
• W2079678670 cites W1977595819 @default.
• W2079678670 cites W1979255869 @default.
• W2079678670 cites W1983118029 @default.
• W2079678670 cites W1985909917 @default.
• W2079678670 cites W1990432209 @default.
• W2079678670 cites W1997213046 @default.
• W2079678670 cites W2011487988 @default.
• W2079678670 cites W2016370879 @default.
• W2079678670 cites W2021186617 @default.
• W2079678670 cites W2028656620 @default.
• W2079678670 cites W2034769638 @default.
• W2079678670 cites W2037295316 @default.
• W2079678670 cites W2042969301 @default.
• W2079678670 cites W2045672376 @default.
• W2079678670 cites W2049481764 @default.
• W2079678670 cites W2051834155 @default.
• W2079678670 cites W2052501221 @default.
• W2079678670 cites W2065363098 @default.
• W2079678670 cites W2070172669 @default.
• W2079678670 cites W2071579267 @default.
• W2079678670 cites W2095417854 @default.
• W2079678670 cites W2100912424 @default.
• W2079678670 cites W2101351031 @default.
• W2079678670 cites W2110075716 @default.
• W2079678670 cites W2113877558 @default.
• W2079678670 cites W2119627241 @default.
• W2079678670 cites W2124496590 @default.
• W2079678670 cites W2128057829 @default.
• W2079678670 cites W2134822922 @default.
• W2079678670 cites W2139815513 @default.
• W2079678670 cites W2149343591 @default.
• W2079678670 cites W2155605721 @default.
• W2079678670 cites W2162539094 @default.
• W2079678670 cites W2170887564 @default.
• W2079678670 cites W2257711744 @default.
• W2079678670 cites W2317210331 @default.
• W2079678670 cites W2413432844 @default.
• W2079678670 doi "https://doi.org/10.1152/japplphysiol.00031.2011" @default.
• W2079678670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3174792" @default.
• W2079678670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21680879" @default.
• W2079678670 hasPublicationYear "2011" @default.
• W2079678670 type Work @default.
• W2079678670 sameAs 2079678670 @default.
• W2079678670 citedByCount "13" @default.
• W2079678670 countsByYear W20796786702012 @default.
• W2079678670 countsByYear W20796786702013 @default.
• W2079678670 countsByYear W20796786702016 @default.
• W2079678670 countsByYear W20796786702018 @default.
• W2079678670 countsByYear W20796786702020 @default.
• W2079678670 countsByYear W20796786702021 @default.
• W2079678670 countsByYear W20796786702022 @default.
• W2079678670 crossrefType "journal-article" @default.
• W2079678670 hasAuthorship W2079678670A5003919068 @default.
• W2079678670 hasAuthorship W2079678670A5012718640 @default.
• W2079678670 hasAuthorship W2079678670A5026699951 @default.
• W2079678670 hasAuthorship W2079678670A5035485086 @default.
• W2079678670 hasBestOaLocation W20796786702 @default.
• W2079678670 hasConcept C104317684 @default.
• W2079678670 hasConcept C115725540 @default.
• W2079678670 hasConcept C126322002 @default.
• W2079678670 hasConcept C134018914 @default.
• W2079678670 hasConcept C144469398 @default.
• W2079678670 hasConcept C174054327 @default.
• W2079678670 hasConcept C185592680 @default.
• W2079678670 hasConcept C2776104385 @default.
• W2079678670 hasConcept C2779959927 @default.
• W2079678670 hasConcept C36036425 @default.
• W2079678670 hasConcept C500558357 @default.
• W2079678670 hasConcept C53345823 @default.
• W2079678670 hasConcept C55493867 @default.
• W2079678670 hasConcept C6997183 @default.
• W2079678670 hasConcept C71924100 @default.
• W2079678670 hasConcept C86803240 @default.
• W2079678670 hasConceptScore W2079678670C104317684 @default.
• W2079678670 hasConceptScore W2079678670C115725540 @default.
• W2079678670 hasConceptScore W2079678670C126322002 @default.
• W2079678670 hasConceptScore W2079678670C134018914 @default.
• W2079678670 hasConceptScore W2079678670C144469398 @default.
• W2079678670 hasConceptScore W2079678670C174054327 @default.
• W2079678670 hasConceptScore W2079678670C185592680 @default.
• W2079678670 hasConceptScore W2079678670C2776104385 @default.

• next