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• W2079678859 abstract "Asiatic acid, a triterpenoid derivative from Centella asiatica, has shown biological effects such as antioxidant, antiinflammatory, and protection against glutamate- or beta-amyloid-induced neurotoxicity. We investigated the neuroprotective effect of asiatic acid in a mouse model of permanent cerebral ischemia. Various doses of asiatic acid (30, 75, or 165 mg/kg) were administered orally at 1 hr pre- and 3, 10, and 20 hr postischemia, and infarct volume and behavioral deficits were evaluated at day 1 or 7 postischemia. IgG (blood-brain barrier integrity) and cytochrome c (apoptosis) immunostaining was carried out at 24 hr postischemia. The effect of asiatic acid on stress-induced cytochrome c release was examined in isolated mitochondrial fractions. Furthermore, its effects on cell viability and mitochondrial membrane potential were studied in HT-22 cells exposed to oxygen-glucose deprivation. Asiatic acid significantly reduced the infarct volume by 60% at day 1 and by 26% at day 7 postischemia and improved neurological outcome at 24 hr postischemia. Our studies also showed that the neuroprotective properties of asiatic acid might be mediated in part through decreased blood-brain barrier permeability and reduction in mitochondrial injury. The present study suggests that asiatic acid may be useful in the treatment of cerebral ischemia." @default.
• W2079678859 created "2016-06-24" @default.
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• W2079678859 date "2009-08-15" @default.
• W2079678859 modified "2023-10-06" @default.
• W2079678859 title "Asiatic acid, a pentacyclic triterpene from<i>Centella asiatica</i>, is neuroprotective in a mouse model of focal cerebral ischemia" @default.
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• W2079678859 doi "https://doi.org/10.1002/jnr.22071" @default.
• W2079678859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2941770" @default.
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