FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079680315> ?p ?o ?g. }

• W2079680315 endingPage "55" @default.
• W2079680315 startingPage "43" @default.
• W2079680315 abstract "The liver microsomal fractions of seven mammalian species including rat, dog, monkey, hamster, mouse, gerbil and humans, catalyzed the hydroxylation of saturated (lauric, myristic and palmitic) and unsaturated (oleic and linoleic) fatty acids to the corresponding ω and (ω-1)-hydroxylated derivatives, while stearic acid was not metabolized. Lauric acid was the most efficiently hydroxylated, and the rank of catalytic activity was lauric>myristic>oleic>palmitic>linoleic. Among the mammalian species studied, mouse and hamster presented the highest level of fatty acid ω and (ω-1)-hydroxylases, while the lowest activity was observed in dog and monkey. In all the animal species, the (ω-1)-hydroxylation of fatty acids correlated significantly with the immunodetectable content of CYP2E1 and the 4-nitrophenol hydroxylation activity, known to be mediated by cytochrome P450 2E1. On the contrary, only the ω-hydroxylation of lauric acid slighly correlated with the level of cytochrome P450 4A, while no significant correlation was found with the ω-hydroxylation of the other fatty acids. Furthermore, chemical and immuno-inhibitions of the hydroxylations of fatty acids led to the conclusion that fatty acid (ω-1)-hydroxylase activity is catalyzed by P450 2E1 in all the mammalian species, while the fatty acid ω-hydroxylase activity may be catalyzed by cytochromes P450 from the 4A family. Therefore, lauric acid (ω-1)-hydroxylation along with 4-nitrophenol hydroxylation can be used as a specific and sensitive method to measure the level of CYP2E1 induction in humans and various animals." @default.
• W2079680315 created "2016-06-24" @default.
• W2079680315 creator A5017649299 @default.
• W2079680315 creator A5026783868 @default.
• W2079680315 creator A5026815006 @default.
• W2079680315 creator A5045288162 @default.
• W2079680315 creator A5066569268 @default.
• W2079680315 date "1999-10-01" @default.
• W2079680315 modified "2023-09-25" @default.
• W2079680315 title "Interspecies variations in fatty acid hydroxylations involving cytochromes P450 2E1 and 4A" @default.
• W2079680315 cites W1493785014 @default.
• W2079680315 cites W1840949997 @default.
• W2079680315 cites W1847827438 @default.
• W2079680315 cites W1966369988 @default.
• W2079680315 cites W1968563067 @default.
• W2079680315 cites W1978522903 @default.
• W2079680315 cites W1983919180 @default.
• W2079680315 cites W1984526747 @default.
• W2079680315 cites W1993465296 @default.
• W2079680315 cites W1996968257 @default.
• W2079680315 cites W1997048544 @default.
• W2079680315 cites W1999327856 @default.
• W2079680315 cites W2004984762 @default.
• W2079680315 cites W2005742461 @default.
• W2079680315 cites W2006998778 @default.
• W2079680315 cites W2010341202 @default.
• W2079680315 cites W2014378716 @default.
• W2079680315 cites W2021219604 @default.
• W2079680315 cites W2024132020 @default.
• W2079680315 cites W2027376002 @default.
• W2079680315 cites W2029733973 @default.
• W2079680315 cites W2031637185 @default.
• W2079680315 cites W2037679410 @default.
• W2079680315 cites W2039315523 @default.
• W2079680315 cites W2043263657 @default.
• W2079680315 cites W2052428509 @default.
• W2079680315 cites W2053837499 @default.
• W2079680315 cites W2056992552 @default.
• W2079680315 cites W2075200935 @default.
• W2079680315 cites W2075522186 @default.
• W2079680315 cites W2088524561 @default.
• W2079680315 cites W2090149382 @default.
• W2079680315 cites W2092615420 @default.
• W2079680315 cites W2094088114 @default.
• W2079680315 cites W2094932400 @default.
• W2079680315 cites W2100837269 @default.
• W2079680315 cites W2101108802 @default.
• W2079680315 cites W2109448546 @default.
• W2079680315 cites W2114168797 @default.
• W2079680315 cites W2135536512 @default.
• W2079680315 cites W2143871691 @default.
• W2079680315 cites W2163891284 @default.
• W2079680315 cites W2166494544 @default.
• W2079680315 cites W2177492036 @default.
• W2079680315 cites W2187858787 @default.
• W2079680315 cites W2403675971 @default.
• W2079680315 cites W37725492 @default.
• W2079680315 cites W968781259 @default.
• W2079680315 doi "https://doi.org/10.1016/s0378-4274(99)00140-x" @default.
• W2079680315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10593594" @default.
• W2079680315 hasPublicationYear "1999" @default.
• W2079680315 type Work @default.
• W2079680315 sameAs 2079680315 @default.
• W2079680315 citedByCount "31" @default.
• W2079680315 countsByYear W20796803152013 @default.
• W2079680315 countsByYear W20796803152014 @default.
• W2079680315 countsByYear W20796803152015 @default.
• W2079680315 countsByYear W20796803152016 @default.
• W2079680315 countsByYear W20796803152017 @default.
• W2079680315 countsByYear W20796803152018 @default.
• W2079680315 countsByYear W20796803152020 @default.
• W2079680315 countsByYear W20796803152021 @default.
• W2079680315 countsByYear W20796803152022 @default.
• W2079680315 crossrefType "journal-article" @default.
• W2079680315 hasAuthorship W2079680315A5017649299 @default.
• W2079680315 hasAuthorship W2079680315A5026783868 @default.
• W2079680315 hasAuthorship W2079680315A5026815006 @default.
• W2079680315 hasAuthorship W2079680315A5045288162 @default.
• W2079680315 hasAuthorship W2079680315A5066569268 @default.
• W2079680315 hasConcept C134018914 @default.
• W2079680315 hasConcept C140027455 @default.
• W2079680315 hasConcept C181199279 @default.
• W2079680315 hasConcept C185592680 @default.
• W2079680315 hasConcept C2778483698 @default.
• W2079680315 hasConcept C2778575167 @default.
• W2079680315 hasConcept C2779936771 @default.
• W2079680315 hasConcept C2780809830 @default.
• W2079680315 hasConcept C2781003072 @default.
• W2079680315 hasConcept C2781109383 @default.
• W2079680315 hasConcept C2781403372 @default.
• W2079680315 hasConcept C526171541 @default.
• W2079680315 hasConcept C543025807 @default.
• W2079680315 hasConcept C55493867 @default.
• W2079680315 hasConcept C62231903 @default.
• W2079680315 hasConcept C86803240 @default.
• W2079680315 hasConceptScore W2079680315C134018914 @default.
• W2079680315 hasConceptScore W2079680315C140027455 @default.
• W2079680315 hasConceptScore W2079680315C181199279 @default.

• next