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- W2079681684 abstract "In this study, we assessed the temporal variation in the hypnotic effect of etomidate, a drug that positively modulates GABA A -mediated neurotransmission in the Syrian hamster. Ten to twenty mg/kg of etomidate i.p. induced a significant loss of righting reflex when administered at 12:00 h but not 24:00 h in hamsters housed under a 14 : 10 light : dark photoperiod (lights on at 06:00 h). On the contrary, ketamine (administered together with xylazine), which induces anesthesia by inhibiting glutamatergic neurotransmission, did not show a diurnal variation in the loss of righting reflex test. These results support previous data regarding diurnal rhythms in GABA content and activity. The phase dependent response to etomidate may be due to daily allosteric modulation of the GABAA receptor." @default.
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- W2079681684 date "2002-10-01" @default.
- W2079681684 modified "2023-09-27" @default.
- W2079681684 title "Time-dependent Etomidate-induced Anesthesia in Hamsters" @default.
- W2079681684 doi "https://doi.org/10.1076/brhm.33.4.437.8806" @default.
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