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- W2079683131 abstract "Recently, there has been increasing research focused on the use of natural killer (NK) cells to treat cancer. NK cells mediate MHC-independent cytotoxicity against tumor cells, and in tumor-bearing mice adoptive infusions of ex vivo-expanded syngeneic or LY-49-incompatible allogeneic NK cells delay tumor growth and prolong survival ( 1. Lundqvist A. McCoy J.P. Samsel L. Childs R. Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors. Blood. 2007; 109: 3603-3606 Crossref PubMed Scopus (82) Google Scholar ). In humans, pilot studies have shown that adoptive transfer of IL-2-activated KIR-incompatible NK cells can be associated with responses in patients with a variety of malignancies [reviewed in ( 2. Sutlu T. Alici E. Natural killer cell-based immunotherapy in cancer: current insights and future prospects. J Intern Med. 2009; 266: 154-181 Crossref PubMed Scopus (158) Google Scholar )]. Despite these observations, the therapeutic potential of NK cell-based immunotherapy remains largely unknown, as difficulties in developing a method that reliably expands large numbers of NK cells ex vivo have slowed the development of adoptive NK cell trials for cancer. Recently investigators have shown that irradiated allogeneic feeder cells such as EBV-transformed B cells or genetically engineered K562 cells can be used to expand substantial numbers of highly activated clinical-grade NK cells in vitro ( 3. Berg M. Lundqvist A. McCoy Jr., P. Samsel L. Fan Y. Tawab A. et al. Clinical-grade ex vivo-expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells. Cytotherapy. 2009; 11: 341-355 Abstract Full Text Full Text PDF PubMed Scopus (223) Google Scholar , 4. Imai C. Iwamoto S. Campana D. Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood. 2005; 106: 376-383 Crossref PubMed Scopus (489) Google Scholar ). Because T cells will also expand in these culture conditions, T-cell depletion of PBMCs with or without CD56 selection immediately prior to the initiation of the cell culture has been used to obtain a highly pure expanded NK-cell product." @default.
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- W2079683131 date "2010-12-01" @default.
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- W2079683131 title "Ex-vivo expansion of NK cells: What is the priority - high yield or high purity?" @default.
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- W2079683131 doi "https://doi.org/10.3109/14653249.2010.536216" @default.
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