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- W2079683770 endingPage "228" @default.
- W2079683770 startingPage "228" @default.
- W2079683770 abstract "The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare monogenic diseases, as well as some more common polygenic conditions. Bacterial wall constituents and other cellular stressor molecules are recognized by a range of NLRs, which leads to activation of the innate immune response and upregulation of key proinflammatory pathways, such as IL-1β production and translocation of nuclear factor-κB to the nucleus. These signalling pathways are increasingly being targeted as potential sites for new therapies. This review discusses the role played by NLRs in a variety of inflammatory diseases and describes the remarkable success to date of these therapeutic agents in treating some of the disorders associated with aberrant NLR function." @default.
- W2079683770 created "2016-06-24" @default.
- W2079683770 creator A5006578185 @default.
- W2079683770 creator A5023456583 @default.
- W2079683770 creator A5067816670 @default.
- W2079683770 date "2008-01-01" @default.
- W2079683770 modified "2023-10-08" @default.
- W2079683770 title "NOD-like receptors and inflammation" @default.
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