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- W2079684345 abstract "Although the distribution of opioid receptors is central to the patch-matrix model of neostriatal organization, it has been unclear whether these receptors are located post-synaptically. Moreover, it has not yet been clarified whether opioid receptor activation in neostriatum results in the modulation of calcium and/or potassium conductances. To test this, neostriatal neurons were acutely isolated and their sensitivity to opioid receptor agonists determined. At nanomolar. At nanomolar concentrations, both the μ-agonist [d-Ala2, MePhe4, Gly-ol5]-enkephalin (DAMGO) and the δ-agonist [d-Pen2, d-Pen5]-enkephalin (DPEPE) reversibly decreased whole-cell calcium currents in medium-sized neurons. These effects were blocked by the opiate antagonist naloxone. These findings argue that activation of post-synaptic, opioid receptors is capable of modulating the excitability of neostriatal neurons." @default.
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- W2079684345 title "Opioids decrease high-voltage activated calcium currents in acutely dissociated neostriatal neurons" @default.
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- W2079684345 doi "https://doi.org/10.1016/0006-8993(94)90940-7" @default.
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