FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079686541> ?p ?o ?g. }

• W2079686541 endingPage "8" @default.
• W2079686541 startingPage "1" @default.
• W2079686541 abstract "Cell-penetrating peptides (CPPs) are short cationic peptides that have been extensively studied as drug delivery vehicles for proteins, nucleic acids and nanoparticles. However, the formulation of CPP-based therapeutics into different pharmaceutical formulations and their stability in relevant biological environments have not been given the same attention. Here, we show that a newly developed CPP, PepFect 14 (PF14), forms non-covalent nanocomplexes with short interfering RNA (siRNA), which are able to elicit efficient RNA-interference (RNAi) response in different cell-lines. RNAi effect is obtained at low siRNA doses with a unique kinetic profile. Furthermore, the solid dispersion technique is utilized to formulate PF14/siRNA nanocomplexes into solid formulations that are as active as the freshly prepared nanocomplexes in solution. Importantly, the nanocomplexes are stable and active in mediating RNAi response after incubation with simulated gastric fluid (SGF) that is highly acidic. These results demonstrate the activity of PF14 in delivering and protecting siRNA in different pharmaceutical forms and biological environments." @default.
• W2079686541 created "2016-06-24" @default.
• W2079686541 creator A5000079194 @default.
• W2079686541 creator A5004361832 @default.
• W2079686541 creator A5005513407 @default.
• W2079686541 creator A5015978312 @default.
• W2079686541 creator A5036357426 @default.
• W2079686541 creator A5057501316 @default.
• W2079686541 creator A5059897226 @default.
• W2079686541 creator A5073222884 @default.
• W2079686541 date "2012-08-01" @default.
• W2079686541 modified "2023-10-13" @default.
• W2079686541 title "Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions" @default.
• W2079686541 cites W1515068677 @default.
• W2079686541 cites W1964146045 @default.
• W2079686541 cites W1971409649 @default.
• W2079686541 cites W1975875150 @default.
• W2079686541 cites W1985222229 @default.
• W2079686541 cites W1985719826 @default.
• W2079686541 cites W2013848827 @default.
• W2079686541 cites W2017714283 @default.
• W2079686541 cites W2027587162 @default.
• W2079686541 cites W2029766213 @default.
• W2079686541 cites W2036408851 @default.
• W2079686541 cites W2036939362 @default.
• W2079686541 cites W2052530916 @default.
• W2079686541 cites W2088960285 @default.
• W2079686541 cites W2089150369 @default.
• W2079686541 cites W2095151181 @default.
• W2079686541 cites W2108224709 @default.
• W2079686541 cites W2120466274 @default.
• W2079686541 cites W2127677388 @default.
• W2079686541 cites W2131083445 @default.
• W2079686541 cites W2141547126 @default.
• W2079686541 cites W2144072026 @default.
• W2079686541 cites W2150685110 @default.
• W2079686541 cites W2151163354 @default.
• W2079686541 cites W2153940274 @default.
• W2079686541 cites W242113310 @default.
• W2079686541 cites W4205948329 @default.
• W2079686541 doi "https://doi.org/10.1016/j.jconrel.2012.06.006" @default.
• W2079686541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7126485" @default.
• W2079686541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22698942" @default.
• W2079686541 hasPublicationYear "2012" @default.
• W2079686541 type Work @default.
• W2079686541 sameAs 2079686541 @default.
• W2079686541 citedByCount "49" @default.
• W2079686541 countsByYear W20796865412012 @default.
• W2079686541 countsByYear W20796865412013 @default.
• W2079686541 countsByYear W20796865412014 @default.
• W2079686541 countsByYear W20796865412015 @default.
• W2079686541 countsByYear W20796865412016 @default.
• W2079686541 countsByYear W20796865412017 @default.
• W2079686541 countsByYear W20796865412018 @default.
• W2079686541 countsByYear W20796865412019 @default.
• W2079686541 countsByYear W20796865412020 @default.
• W2079686541 countsByYear W20796865412021 @default.
• W2079686541 countsByYear W20796865412022 @default.
• W2079686541 countsByYear W20796865412023 @default.
• W2079686541 crossrefType "journal-article" @default.
• W2079686541 hasAuthorship W2079686541A5000079194 @default.
• W2079686541 hasAuthorship W2079686541A5004361832 @default.
• W2079686541 hasAuthorship W2079686541A5005513407 @default.
• W2079686541 hasAuthorship W2079686541A5015978312 @default.
• W2079686541 hasAuthorship W2079686541A5036357426 @default.
• W2079686541 hasAuthorship W2079686541A5057501316 @default.
• W2079686541 hasAuthorship W2079686541A5059897226 @default.
• W2079686541 hasAuthorship W2079686541A5073222884 @default.
• W2079686541 hasBestOaLocation W20796865411 @default.
• W2079686541 hasConcept C104317684 @default.
• W2079686541 hasConcept C12554922 @default.
• W2079686541 hasConcept C13245373 @default.
• W2079686541 hasConcept C1491633281 @default.
• W2079686541 hasConcept C15083742 @default.
• W2079686541 hasConcept C155672457 @default.
• W2079686541 hasConcept C166703698 @default.
• W2079686541 hasConcept C171250308 @default.
• W2079686541 hasConcept C178790620 @default.
• W2079686541 hasConcept C185592680 @default.
• W2079686541 hasConcept C192562407 @default.
• W2079686541 hasConcept C22615655 @default.
• W2079686541 hasConcept C24107716 @default.
• W2079686541 hasConcept C2776929087 @default.
• W2079686541 hasConcept C2779281246 @default.
• W2079686541 hasConcept C2779820397 @default.
• W2079686541 hasConcept C54355233 @default.
• W2079686541 hasConcept C55493867 @default.
• W2079686541 hasConcept C67705224 @default.
• W2079686541 hasConcept C81885089 @default.
• W2079686541 hasConcept C86803240 @default.
• W2079686541 hasConceptScore W2079686541C104317684 @default.
• W2079686541 hasConceptScore W2079686541C12554922 @default.
• W2079686541 hasConceptScore W2079686541C13245373 @default.
• W2079686541 hasConceptScore W2079686541C1491633281 @default.
• W2079686541 hasConceptScore W2079686541C15083742 @default.
• W2079686541 hasConceptScore W2079686541C155672457 @default.
• W2079686541 hasConceptScore W2079686541C166703698 @default.
• W2079686541 hasConceptScore W2079686541C171250308 @default.

• next