FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079687595> ?p ?o ?g. }

• W2079687595 endingPage "1079" @default.
• W2079687595 startingPage "1065" @default.
• W2079687595 abstract "A series of in vivo studies have been carried out using the chick embryo to address several critical questions concerning the biological, and to a lesser extent, the biochemical characteristics of a putative avian muscle-derived trophic agent that promotes motoneuron survival in vivo. A partially purified fraction of muscle extract was shown to be heat and trypsin sensitive and rescued motoneurons from naturally occurring cell death in a dose-dependent fashion. Muscle extract had no effect on mitotic activity in the spinal cord and did not alter cell number when administered either before or after the normal cell death period. The survival promoting activity in the muscle extract appears to be developmentally regulated. Treatment with muscle extract during the cell death period did not permanently rescue motoneurons. The motoneuron survival-promoting activity found in skeletal muscle was not present in extracts from a variety of other tissues, including liver, kidney, lung, heart, and smooth muscle. Survival activity was also found in extracts from fetal mouse, rat, and human skeletal muscle. Conditioned medium derived from avian myotube cultures also prevented motoneuron death when administered in vivo to chick embryos. Treatment of embryos in ovo with muscle extract had no effect on several properties of developing muscles. With the exception of cranial motoneurons, treatment with muscle extract did not promote the survival of several other populations of neurons in the central and peripheral nervous system that also exhibit naturally occurring cell death. Initial biochemical characterization suggests that the activity in skeletal muscle is an acidic protein between 10 and 30 kD. Examination of a number of previously characterized growth and trophic agents in our in vivo assay have identified several molecules that promote motoneuron survival to one degree or another. These include S100 beta, brain-derived neurotrophic factor (BDNF), neurotrophin 4/5 (NT-4/5), ciliary neurotrophic factor (CNTF), transforming growth factor beta (TGF beta), platelet-derived growth factor-AB (PDGF-AB), leukemia inhibitory factor (CDF/LIF), and insulin-like growth factors I and II (IGF). By contrast, the following agents were ineffective: nerve growth factor (NGF), neurotrophin-3 (NT3), epidermal growth factor (EGF), acidic and basic fibroblast growth factors (aFGF, bFGF), and the heparin-binding growth-associated molecule (HB-GAM).(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2079687595 created "2016-06-24" @default.
• W2079687595 creator A5015039309 @default.
• W2079687595 creator A5043555694 @default.
• W2079687595 creator A5053841422 @default.
• W2079687595 creator A5059117163 @default.
• W2079687595 creator A5074335629 @default.
• W2079687595 creator A5081644839 @default.
• W2079687595 date "1993-08-01" @default.
• W2079687595 modified "2023-09-27" @default.
• W2079687595 title "Biological studies of a putative avian muscle-derived neurotrophic factor that prevents naturally occurring motoneuron deathin vivo" @default.
• W2079687595 cites W1488158930 @default.
• W2079687595 cites W1501840877 @default.
• W2079687595 cites W1517125774 @default.
• W2079687595 cites W1527035699 @default.
• W2079687595 cites W1607227152 @default.
• W2079687595 cites W1619823267 @default.
• W2079687595 cites W1635109674 @default.
• W2079687595 cites W1775749144 @default.
• W2079687595 cites W1905071397 @default.
• W2079687595 cites W1964336177 @default.
• W2079687595 cites W1966126634 @default.
• W2079687595 cites W1969102549 @default.
• W2079687595 cites W1969943683 @default.
• W2079687595 cites W1974479702 @default.
• W2079687595 cites W1977556956 @default.
• W2079687595 cites W1979566783 @default.
• W2079687595 cites W1980234513 @default.
• W2079687595 cites W1981238340 @default.
• W2079687595 cites W1985933922 @default.
• W2079687595 cites W1993658603 @default.
• W2079687595 cites W1996362183 @default.
• W2079687595 cites W1999259470 @default.
• W2079687595 cites W2002265951 @default.
• W2079687595 cites W2003054104 @default.
• W2079687595 cites W2003585900 @default.
• W2079687595 cites W2005044527 @default.
• W2079687595 cites W2005447528 @default.
• W2079687595 cites W2006485431 @default.
• W2079687595 cites W2008291157 @default.
• W2079687595 cites W2008392500 @default.
• W2079687595 cites W2008691747 @default.
• W2079687595 cites W2009176974 @default.
• W2079687595 cites W2009649222 @default.
• W2079687595 cites W2016057166 @default.
• W2079687595 cites W2018068734 @default.
• W2079687595 cites W2023142792 @default.
• W2079687595 cites W2024077613 @default.
• W2079687595 cites W2027724538 @default.
• W2079687595 cites W2031088535 @default.
• W2079687595 cites W2031468048 @default.
• W2079687595 cites W2035009094 @default.
• W2079687595 cites W2036083437 @default.
• W2079687595 cites W2036176120 @default.
• W2079687595 cites W2040286934 @default.
• W2079687595 cites W2045951428 @default.
• W2079687595 cites W2046739492 @default.
• W2079687595 cites W2050119939 @default.
• W2079687595 cites W2051600135 @default.
• W2079687595 cites W2052659902 @default.
• W2079687595 cites W2056041896 @default.
• W2079687595 cites W2060236013 @default.
• W2079687595 cites W2060628901 @default.
• W2079687595 cites W2060825405 @default.
• W2079687595 cites W2064117255 @default.
• W2079687595 cites W2064379794 @default.
• W2079687595 cites W2064963239 @default.
• W2079687595 cites W2065323232 @default.
• W2079687595 cites W2080880626 @default.
• W2079687595 cites W2084595515 @default.
• W2079687595 cites W2091222457 @default.
• W2079687595 cites W2092025476 @default.
• W2079687595 cites W2094073595 @default.
• W2079687595 cites W2097939870 @default.
• W2079687595 cites W2107385913 @default.
• W2079687595 cites W2114154263 @default.
• W2079687595 cites W2119399526 @default.
• W2079687595 cites W2125586901 @default.
• W2079687595 cites W2133162152 @default.
• W2079687595 cites W2140034535 @default.
• W2079687595 cites W2154745705 @default.
• W2079687595 cites W2156688450 @default.
• W2079687595 cites W2171632352 @default.
• W2079687595 cites W2171973197 @default.
• W2079687595 cites W2346002398 @default.
• W2079687595 cites W4231757705 @default.
• W2079687595 cites W4232534952 @default.
• W2079687595 cites W4247752893 @default.
• W2079687595 doi "https://doi.org/10.1002/neu.480240806" @default.
• W2079687595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8409968" @default.
• W2079687595 hasPublicationYear "1993" @default.
• W2079687595 type Work @default.
• W2079687595 sameAs 2079687595 @default.
• W2079687595 citedByCount "109" @default.
• W2079687595 countsByYear W20796875952012 @default.
• W2079687595 countsByYear W20796875952013 @default.
• W2079687595 countsByYear W20796875952014 @default.
• W2079687595 countsByYear W20796875952015 @default.

• next