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• W2079689069 abstract "RATIONALE: Mast cells (MCs) and dendritic cells (DCs) are components of the innate immune system and also play a significant role in acquired immunity. Because MCs are often found in close physical contact with DCs in the skin and the mucosal surfaces, the preferential sites of pathogen entry and antigen (Ag) exposure, we have hypothesized that the ability of certain Ags to directly activate MCs affect the migration/maturation of the DCs capturing that Ag and thereby regulate the nature of the subsequent primary T cell response.METHODS: MCs were derived from CD34+ progenitors and stimulated with IgE/anti-IgE. Supernatants of these cultures were used to stimulate autologous monocyte-derived DCs.RESULTS: Here we demonstrated that activated MCs or their culture supernatants promoted the maturation of immature DCs into semi-mature DCs expressing CCR7 and co-stimulatory molecules such as HLA-DR, CD80, CD83, and CD86, but secreting little or no cytokines. Moreover, MCs culture supernatants modulated the cytokine production profile of LPS-treated DCs by increasing the production of IL-10 and decreasing that of TNF-α and IL-12. DCs primed with MCs supernatant promoted the development of allogeneic naïve CD4+ T cells into CD103+ cells. These isolated CD103+ T cells suppressed proliferation and cytokine production of activated T cells and contained more FoxP3 than their CD103− counterparts as we have previously described.CONCLUSIONS: Taken together, the data suggest that MCs activation contributes to the development of tolerogenic DCs that induce CD103+ Treg, thus directly implicating MCs in the control of aquired immune responses. RATIONALE: Mast cells (MCs) and dendritic cells (DCs) are components of the innate immune system and also play a significant role in acquired immunity. Because MCs are often found in close physical contact with DCs in the skin and the mucosal surfaces, the preferential sites of pathogen entry and antigen (Ag) exposure, we have hypothesized that the ability of certain Ags to directly activate MCs affect the migration/maturation of the DCs capturing that Ag and thereby regulate the nature of the subsequent primary T cell response. METHODS: MCs were derived from CD34+ progenitors and stimulated with IgE/anti-IgE. Supernatants of these cultures were used to stimulate autologous monocyte-derived DCs. RESULTS: Here we demonstrated that activated MCs or their culture supernatants promoted the maturation of immature DCs into semi-mature DCs expressing CCR7 and co-stimulatory molecules such as HLA-DR, CD80, CD83, and CD86, but secreting little or no cytokines. Moreover, MCs culture supernatants modulated the cytokine production profile of LPS-treated DCs by increasing the production of IL-10 and decreasing that of TNF-α and IL-12. DCs primed with MCs supernatant promoted the development of allogeneic naïve CD4+ T cells into CD103+ cells. These isolated CD103+ T cells suppressed proliferation and cytokine production of activated T cells and contained more FoxP3 than their CD103− counterparts as we have previously described. CONCLUSIONS: Taken together, the data suggest that MCs activation contributes to the development of tolerogenic DCs that induce CD103+ Treg, thus directly implicating MCs in the control of aquired immune responses." @default.
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• W2079689069 date "2007-01-01" @default.
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• W2079689069 title "Mast Cells Promote the Development of CD103+ Regulatory T cells" @default.
• W2079689069 doi "https://doi.org/10.1016/j.jaci.2006.11.207" @default.
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