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- W2079690223 abstract "3′-Radiohalogenated (36Cl, 82Br and 123I) “arabino” pyrimidine nucleosides were evaluated as potential tumor diagnostic agents in tumor bearing animals. No preferential tissue uptake was observed. The compounds were excreted mainly unchanged in the urine. The 3′-[36Cl]- and 3′[82Br]-3′-deoxyarabino nucleosides exhibited biliary uptake. The low uptake of injected radioactivity by the tumor was probably due to the combined effects of the lack of a C-3′ hydroxyl group in the “ribo” configuration, the presence of a halogen, the structural rigidity imposed by the presence of a halogen and the short biological half-lives of the compounds." @default.
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- W2079690223 date "1984-11-01" @default.
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- W2079690223 title "Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models: VI. 1-(3′-[36Cl]-chloro-, 1-(3′-[82Br]-bromo- and 1-(3′-[123I]-iodo-3′-deoxy-β-D-arabinofuranosyl)uracil" @default.
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- W2079690223 doi "https://doi.org/10.1016/0020-708x(84)90010-3" @default.
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