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• W2079697237 abstract "You have accessJournal of UrologyBladder Cancer: Superficial1 Apr 20111751 OUTCOME ANALYSIS OF PATIENTS WITH EXCLUSIVELY CARCINOMA IN SITU (CIS) FOLLOWING RADICAL CYSTECTOMY AND NO PREVIOUS HISTORY OF LAMINA PROPRIA INVASION Pascal Zehnder, Sia Daneshmand, Marya Leahy, Jie Cai, Gus Miranda, Anirban Mitra, Georg Bartsch, Eila Skinner, and Inderbir Gill Pascal ZehnderPascal Zehnder Los Angeles, CA More articles by this author , Sia DaneshmandSia Daneshmand Los Angeles, CA More articles by this author , Marya LeahyMarya Leahy Los Angeles, CA More articles by this author , Jie CaiJie Cai Los Angeles, CA More articles by this author , Gus MirandaGus Miranda Los Angeles, CA More articles by this author , Anirban MitraAnirban Mitra Los Angeles, CA More articles by this author , Georg BartschGeorg Bartsch Los Angeles, CA More articles by this author , Eila SkinnerEila Skinner Los Angeles, CA More articles by this author , and Inderbir GillInderbir Gill Los Angeles, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2078AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Outcome data from clinical or pathological CIS-only cystectomy series comprise inhomogeneous cohorts with considerable stage shifts and consecutively different tumor characteristics. We report oncologic outcomes of patients with CIS only following radical cystectomy and no previous history of lamina propria invasion (equal or higher pT1) disease. METHODS Patients undergoing radical cystectomy and lymphadenectomy with intent to cure at the University of Southern California between 1971 and 2008 were included if they met the following criteria: 1) Preoperative clinical stage CIS and/or Ta, 2) pathological CIS-only disease at cystectomy, 3) no previous history of lamina propria invasion. Survival and recurrence data were analyzed. RESULTS Only 53 of the 1600 patients captured in our database met the inclusion criteria. 38 (72%) patients underwent intravesical instillations prior to cystectomy. Median follow-up was 8.5 years (range: 3d–34y). 15 (28%) patients had unifocal and 38 (72%) patients multifocal disease. A median of 35 lymph nodes (range: 10–95) were removed per patient with no metastasis found. Estimated 5- and 10-year recurrence-free survival rates were 91% and 88%, respectively. Estimated 5- and 10-year overall survival rates were 83% and 64%, respectively. 5 (9%) patients recurred. 3 (6%) patients died from disease, 1 after early local and 1 after early systemic recurrence. 1 patient systemically progressed after stepwise, multifocal urothelial involvement. 1 patient with local recurrence is still alive. Finally, 1 patient with bilateral upper tract recurrence 7 years after radical cystectomy underwent unilateral nephrectomy and contralateral Mitomycin C instillations and is disease free since. CONCLUSIONS To the best of our knowledge, this is the first report on oncologic outcomes of patients with CIS only following radical cystectomy and no previous history of lamina propria invasion. Lifelong follow-up is required as non-invasive urothelial recurrence or metachronous urothelial malignancy may be successfully treatable. However, fatal outcome due to local and systemic recurrence can still occur. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e702-e703 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Pascal Zehnder Los Angeles, CA More articles by this author Sia Daneshmand Los Angeles, CA More articles by this author Marya Leahy Los Angeles, CA More articles by this author Jie Cai Los Angeles, CA More articles by this author Gus Miranda Los Angeles, CA More articles by this author Anirban Mitra Los Angeles, CA More articles by this author Georg Bartsch Los Angeles, CA More articles by this author Eila Skinner Los Angeles, CA More articles by this author Inderbir Gill Los Angeles, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2079697237 title "1751 OUTCOME ANALYSIS OF PATIENTS WITH EXCLUSIVELY CARCINOMA IN SITU (CIS) FOLLOWING RADICAL CYSTECTOMY AND NO PREVIOUS HISTORY OF LAMINA PROPRIA INVASION" @default.
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