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• W2079697265 abstract "The discovery of driver mutations in cancers has raised interest in their suitability as immunotherapeutic targets. A recent study demonstrates that a point mutation in isocitrate dehydrogenase 1 (IDH1R132H), expressed in gliomas and other tumors, is presented on human MHC class II and induces a mutation-specific CD4+ antitumor T cell response in patients and a syngeneic tumor model in MHC-humanized mice." @default.
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• W2079697265 date "2014-12-02" @default.
• W2079697265 modified "2023-10-16" @default.
• W2079697265 title "Mutant IDH1: An immunotherapeutic target in tumors" @default.
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• W2079697265 doi "https://doi.org/10.4161/2162402x.2014.974392" @default.
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