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• W2079698807 abstract "The role of bone marrow (BM) and BM-derived cells in radiation-induced acute gastrointestinal (GI) syndrome is controversial. Here we use bone marrow transplantation (BMT), total body irradiation (TBI) and abdominal irradiation (ABI) models to demonstrate a very limited, if any, role of BM-derived cells in acute GI injury and recovery. Compared with WT BM recipients, mice receiving BM from radiation-resistant PUMA KO mice show no protection from crypt and villus injury or recovery after 15 or 12 Gy TBI, but have a significant survival benefit at 12 Gy TBI. PUMA KO BM significantly protects donor-derived pan-intestinal haematopoietic (CD45+) and endothelial (CD105+) cells after IR. We further show that PUMA KO BM fails to enhance animal survival or crypt regeneration in radiosensitive p21 KO-recipient mice. These findings clearly separate the effects of radiation on the intestinal epithelium from those on the BM and endothelial cells in dose-dependent acute radiation toxicity. Ionizing radiation damages the gastrointestinal system, but the cell types involved in intestinal damage and repair are controversial. Here the authors use bone marrow transplantation models and various irradiation regimes to rule out a role of bone marrow-derived cells in acute gastrointestinal injury and recovery in mice." @default.
• W2079698807 created "2016-06-24" @default.
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• W2079698807 date "2014-03-18" @default.
• W2079698807 modified "2023-10-12" @default.
• W2079698807 title "Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice" @default.
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• W2079698807 doi "https://doi.org/10.1038/ncomms4494" @default.
• W2079698807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4327858" @default.
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• W2079698807 hasPublicationYear "2014" @default.
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