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• W2079700548 abstract "d ‐Aspartate increases human chorionic gonadotropin‐induced testosterone production in purified rat Leydig cells. l ‐Aspartate, d ‐, l ‐glutamate or d ‐, l ‐asparagine could not substitute for d ‐aspartate and this effect was independent of glutamate receptor activation. Testosterone production was enhanced only in cells cultured with d ‐aspartate for more than 3 h. The increased production of testosterone was well correlated with the amounts of d ‐aspartate incorporated into the Leydig cells, and l ‐cysteine sulfinic acid, an inhibitor of d ‐aspartate uptake, suppressed both testosterone production and intracellular d ‐aspartate levels. d ‐Aspartate therefore is presumably taken up into cells to increase steroidogenesis. Intracellular d ‐aspartate probably acts on cholesterol translocation into the inner mitochondrial membrane, the rate‐limiting process in steroidogenesis." @default.
• W2079700548 created "2016-06-24" @default.
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• W2079700548 date "1999-02-12" @default.
• W2079700548 modified "2023-10-06" @default.
• W2079700548 title "<scp>d</scp>‐Aspartate stimulation of testosterone synthesis in rat Leydig cells" @default.
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• W2079700548 doi "https://doi.org/10.1016/s0014-5793(99)00045-9" @default.
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