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- W2079701729 abstract "Multiple myeloma is a plasma cell neoplasm that exploits the surrounding stroma to gain a survival and growth advantage.1 Direct interactions between myeloma cells and stromal cells induce a variety of cytokines (eg, interleukin [IL]-6, IL-10) and growth factors (eg, vascular endothelial growth factor, transforming growth factor-β1). The receptor activator nuclear factor κβ (RANK) pathway is also upregulated, and its activation leads to osteoclast production and bone resorption.1,2 The clinical manifestations of this process include progressive bone destruction, leading to pathologic fractures, spinal cord compression, and hypercalcemia." @default.
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- W2079701729 date "2014-12-01" @default.
- W2079701729 modified "2023-09-25" @default.
- W2079701729 title "Denosumab for the Management of Hypercalcemia of Malignancy in Patients With Multiple Myeloma and Renal Dysfunction" @default.
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- W2079701729 doi "https://doi.org/10.1016/j.clml.2014.07.005" @default.
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