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- W2079703516 abstract "Collaborative analyses of relevant trials are needed to explain the much smaller number of additional cases of cervical intraepithelial neoplasia grade 3 and above (CIN3+) detected by HPV testing in the ARTISTIC trial 1 Kitchener HC Almonte M Thomson C et al. HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial. Lancet Oncol. 2009; 10: 672-682 Summary Full Text Full Text PDF PubMed Scopus (318) Google Scholar than in other apparently similar studies. One important factor mentioned by Sasieni and colleagues was that many cytologically normal women with persistent HPV were not referred to colposcopy before round 2 (the first cytology 26–54 months after entry), mainly because they did not attend for retesting at 12 months. However, the effect is reduced in the combined round 1 and round 2 results, as CIN3+ in late or non-attenders would often be diagnosed in round 2. Further analysis of the ARTISTIC trialThe Lancet Oncology paper by Kitchener and colleagues1 presents results from a major trial of human papillomavirus (HPV) testing in primary cervical screening. It reports that the detection rates for cervical intraepithelial neoplasia grade 3 and above (CIN3+) were almost identical in the two groups in the trial (cytology alone vs cytology plus HPV testing). This finding is different from the results of several other recent randomised trials, and from most other split sample studies.2 Why are the results so different? There are several issues relating to the design, conduct, and data analysis of the ARTISTIC trial that deserve fuller discussion. Full-Text PDF" @default.
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- W2079703516 date "2009-09-01" @default.
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- W2079703516 title "Further analysis of the ARTISTIC trial – Author's reply" @default.
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- W2079703516 doi "https://doi.org/10.1016/s1470-2045(09)70247-5" @default.
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