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- W2079704502 abstract "The literature regarding enkephalin transport through the brain endothelial wall,i.e. the blood-brain barrier (BBB), is conflicting. For example, some studies indicate that enkephalins traverse the BBB at low rates similar to other putative neurotransmitters, while other investigations have indicated that enkephalins readily cross the BBB. In addition, it is possible that enkephalins, like other peptides, such as insulin, do not cross the BBB but actively bind to specific peptide receptors on the luminal side of the BBB. Therefore, the present studies were undertaken with freshly isolated bovine brain cor- tical capillaries to determine if [tyrosyl-3H]leucine enkephalin is either specifically bound or taken up by the cell which comprises the BBB in vivo. Brain capillaries were incubated with radiochemically pure [tyrosyl-3H]leucine enkephalin and [l4C]sucrose, an extracellular space marker, at 22–23 C. The amount of 3H radioactivity associatd with brain endothelia increased with time and reached equilibri..." @default.
- W2079704502 created "2016-06-24" @default.
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- W2079704502 date "1981-10-01" @default.
- W2079704502 modified "2023-09-27" @default.
- W2079704502 title "Enkephalin and Blood-Brain Barrier: Studies of Binding and Degradation in Isolated Brain Micro vessels*" @default.
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- W2079704502 doi "https://doi.org/10.1210/endo-109-4-1138" @default.
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