Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079705163> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2079705163 endingPage "1006" @default.
- W2079705163 startingPage "1001" @default.
- W2079705163 abstract "Peroxisome proliferators (PPs) are non-genotoxic carcinogens in rodents. Their reversible effects on rat liver have been studied with ciprofibrate and fenofibrate. We found that with the hypolipemic drug fenofibrate a pause of 28 days is sufficient for a return to normal status, whereas with the highly potent PP ciprofibrate, the stimulation of ACO mRNA levels remains after its withdrawal. We investigated the effects of the renewal of the treatment with PPs on other peroxisomal parameters and proto-oncogene expression using Wistar rats. Interestingly, c-myc expression was enhanced even upon drug withdrawal, and was more stimulated by the second exposure to ciprofibrate, while c-fos expression was unaltered. However, only slight differences in c-Ha-ras expression were observed. Therefore, the effects of PPs in the Wistar rats are not totally reversible within 28 days following withdrawal, depending on the drug used. These delayed effects of ciprofibrate could be a key to our understanding the hepatocarcinogenic effect of PPs in rodents." @default.
- W2079705163 created "2016-06-24" @default.
- W2079705163 creator A5005641545 @default.
- W2079705163 creator A5018763293 @default.
- W2079705163 creator A5056567555 @default.
- W2079705163 creator A5063954794 @default.
- W2079705163 date "1995-09-01" @default.
- W2079705163 modified "2023-10-17" @default.
- W2079705163 title "Delayed effects of ciprofibrate on rat liver peroxisomal properties and proto-oncogene expression" @default.
- W2079705163 cites W110716922 @default.
- W2079705163 cites W114365888 @default.
- W2079705163 cites W1969499318 @default.
- W2079705163 cites W2014704608 @default.
- W2079705163 cites W2015124930 @default.
- W2079705163 cites W2046579573 @default.
- W2079705163 cites W2060441659 @default.
- W2079705163 cites W2066092624 @default.
- W2079705163 cites W2066935411 @default.
- W2079705163 cites W2073668602 @default.
- W2079705163 cites W2092981603 @default.
- W2079705163 cites W2100837269 @default.
- W2079705163 cites W2130575338 @default.
- W2079705163 cites W2159121645 @default.
- W2079705163 cites W2219509325 @default.
- W2079705163 cites W4293247451 @default.
- W2079705163 doi "https://doi.org/10.1016/0006-2952(95)00229-s" @default.
- W2079705163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7575654" @default.
- W2079705163 hasPublicationYear "1995" @default.
- W2079705163 type Work @default.
- W2079705163 sameAs 2079705163 @default.
- W2079705163 citedByCount "15" @default.
- W2079705163 countsByYear W20797051632012 @default.
- W2079705163 countsByYear W20797051632014 @default.
- W2079705163 crossrefType "journal-article" @default.
- W2079705163 hasAuthorship W2079705163A5005641545 @default.
- W2079705163 hasAuthorship W2079705163A5018763293 @default.
- W2079705163 hasAuthorship W2079705163A5056567555 @default.
- W2079705163 hasAuthorship W2079705163A5063954794 @default.
- W2079705163 hasConcept C114246631 @default.
- W2079705163 hasConcept C121608353 @default.
- W2079705163 hasConcept C126322002 @default.
- W2079705163 hasConcept C127078168 @default.
- W2079705163 hasConcept C134018914 @default.
- W2079705163 hasConcept C170493617 @default.
- W2079705163 hasConcept C185592680 @default.
- W2079705163 hasConcept C187345961 @default.
- W2079705163 hasConcept C24998067 @default.
- W2079705163 hasConcept C2778110834 @default.
- W2079705163 hasConcept C2779496979 @default.
- W2079705163 hasConcept C2779745421 @default.
- W2079705163 hasConcept C2780035454 @default.
- W2079705163 hasConcept C2781018059 @default.
- W2079705163 hasConcept C2910266098 @default.
- W2079705163 hasConcept C29537977 @default.
- W2079705163 hasConcept C55493867 @default.
- W2079705163 hasConcept C71924100 @default.
- W2079705163 hasConcept C86803240 @default.
- W2079705163 hasConcept C98274493 @default.
- W2079705163 hasConceptScore W2079705163C114246631 @default.
- W2079705163 hasConceptScore W2079705163C121608353 @default.
- W2079705163 hasConceptScore W2079705163C126322002 @default.
- W2079705163 hasConceptScore W2079705163C127078168 @default.
- W2079705163 hasConceptScore W2079705163C134018914 @default.
- W2079705163 hasConceptScore W2079705163C170493617 @default.
- W2079705163 hasConceptScore W2079705163C185592680 @default.
- W2079705163 hasConceptScore W2079705163C187345961 @default.
- W2079705163 hasConceptScore W2079705163C24998067 @default.
- W2079705163 hasConceptScore W2079705163C2778110834 @default.
- W2079705163 hasConceptScore W2079705163C2779496979 @default.
- W2079705163 hasConceptScore W2079705163C2779745421 @default.
- W2079705163 hasConceptScore W2079705163C2780035454 @default.
- W2079705163 hasConceptScore W2079705163C2781018059 @default.
- W2079705163 hasConceptScore W2079705163C2910266098 @default.
- W2079705163 hasConceptScore W2079705163C29537977 @default.
- W2079705163 hasConceptScore W2079705163C55493867 @default.
- W2079705163 hasConceptScore W2079705163C71924100 @default.
- W2079705163 hasConceptScore W2079705163C86803240 @default.
- W2079705163 hasConceptScore W2079705163C98274493 @default.
- W2079705163 hasIssue "7" @default.
- W2079705163 hasLocation W20797051631 @default.
- W2079705163 hasLocation W20797051632 @default.
- W2079705163 hasOpenAccess W2079705163 @default.
- W2079705163 hasPrimaryLocation W20797051631 @default.
- W2079705163 hasRelatedWork W1989778505 @default.
- W2079705163 hasRelatedWork W2043573754 @default.
- W2079705163 hasRelatedWork W2077066994 @default.
- W2079705163 hasRelatedWork W2079705163 @default.
- W2079705163 hasRelatedWork W2094000826 @default.
- W2079705163 hasRelatedWork W2163771634 @default.
- W2079705163 hasRelatedWork W2333347935 @default.
- W2079705163 hasRelatedWork W2397501423 @default.
- W2079705163 hasRelatedWork W3095396 @default.
- W2079705163 hasRelatedWork W4238501514 @default.
- W2079705163 hasVolume "50" @default.
- W2079705163 isParatext "false" @default.
- W2079705163 isRetracted "false" @default.
- W2079705163 magId "2079705163" @default.
- W2079705163 workType "article" @default.